Health Condition 1: H352- Other non-diabetic proliferative retinopathy
Conditions
Interventions
None listed
Sponsors
Ms Preethi Naik
Applied for ICMR small extramural grants Proposal Id IIRPSG
Eligibility
Inclusion criteria
Inclusion criteria: Type II Diabetes Mellitus: 1. Those who write and read in Kannada/ English 2. Type-2 DM minimum period of condition for one year 3. Best corrected visual acuity (BCVA) better than 6/12 for distance and near N6 at 40cm Diabetic Retinopathy: 1. Those who write and read in Kannada/ English 2. Presence of type 2 DM minimum duration of condition for one year with the diabetic retinopathy 3. BCVA better than 6/12 for distance and near N6 at 40cm Diabetic Neuropathy: 1. Those who write and read in Kannada/English 2. Presence of type 2 DM minimum duration of condition for one year with the diabetic neuropathy 3. BCVA better than 6/12 for distance and near N6 at 40cm Age-matched normal: 1. Those who write and read in Kannada/English 2. Those who are non-diabetic 3. BCVA better than 6/12 for distance and near N6 at 40cm
Exclusion criteria
Exclusion criteria: Type II Diabetes Mellitus: 1. History of glaucoma, Age-related macular degeneration, hypertensive retinopathy 2. Individuals who have Neurological disorders, Parkinson’s disease, psychiatric conditions, Alzheimer’s disease, and Cerebrovascular disease 3. Presence of diabetic neuropathies and diabetic retinopathy Diabetic Retinopathy: 1. History of glaucoma, Age-related macular degeneration, hypertensive retinopathy 2. Individuals who have Neurological disorders, Parkinson’s disease, psychiatric conditions, Alzheimer’s disease, and Cerebrovascular disease 3. Presence of diabetic neuropathies Diabetic Neuropathy: 1. History of glaucoma, Age-related macular degeneration, hypertensive retinopathy 2. Individuals who have Neurological disorders, Parkinson’s disease, psychiatric conditions, Alzheimer’s disease, and Cerebrovascular disease 3. Presence of diabetic retinopathy Age-matched normal: 1. History of glaucoma, Age-related macular degeneration, hypertensive retinopathy 2. Individuals who have Neurological disorders, Parkinson’s disease, psychiatric conditions, Alzheimer’s disease, and Cerebrovascular disease 3. No retinal changes
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| • Cognitive functions will be evaluated by using MoCA – total scores of MoCA will be noted • Visual perception will be assessed by using the Motor free visual perceptual skills test (MVPT-4) – Raw score of MVPT will be noted • Retinal nerve fiber layer thickness in µm • Vessel density in percentage • Foveal avascular zone area in mm2 • Avascular density in percentage • Blood biomarkers - Neurofilament light chain (NFL), Glycated Haemoglobin, lipid profile, C-PeptideTimepoint: 48 months | — |
Secondary
| Measure | Time frame |
|---|---|
| • Cognitive functions will be evaluated by using MoCA – total scores of MoCA will be noted • Visual perception will be assessed by using the Motor free visual perceptual skills test (MVPT-4) – Raw score of MVPT will be noted • Retinal nerve fiber layer thickness in µm • Vessel density in percentage • Foveal avascular zone area in mm2 • Avascular density in percentage • Blood biomarkers - Neurofilament light chain (NFL), Glycated Haemoglobin, lipid profile, C-PeptideTimepoint: 48 months | — |
Countries
India
Contacts
Public ContactPreethi Naik
Kasturba Medical College Manipal Academy of Higher Education
Outcome results
None listed