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Effect of 3 anaesthetic drugs on blood sugars and cortisol in gastrointestinal surgery

Effect of induction of general anaesthesia with etomidate, propofol and thiopentone on serum cortisol and blood sugars in diabetic patients undergoing open gastrointestinal surgery – A randomized controlled study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/075923
Enrollment
40
Registered
2024-10-25
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Etomidate Group (EC): Etomidate induction : Single IV bolus 0.3 mg/kg in non diabetic patients Intervention2: Etomidate group (ED): IV Etomidate 0.3 mg/kg single bolus induction in di

Sponsors

Dr Indira Gurajala
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Diabetic patients of either gender aged 18 to 70 years undergoing elective open gastrointestinal surgery with duration 4-8 hours under combined general and epidural anaesthesia will be included as test groups (PD, TD, ED) . 2. Non-diabetic patients of either gender aged 18 to 70 years undergoing elective open gastrointestinal surgery with duration 4-8 hours under combined general and epidural anaesthesia will be included as control group (EC). 3. preoperative HbA1C of less than 8 %.

Exclusion criteria

Exclusion criteria: 1.hepato- biliary and pancreatic surgeries 2. other concomitant endocrine disorders, 3. receiving preop/intraop steroids and beta-blockers, 4.renal or hepatic disease and 5.Pregnant or lactating women 6.intraoperative Blood loss more than 500 ml 7. surgeries more than 8 hours duration

Design outcomes

Primary

MeasureTime frame
to compare S. cortisol levels at 4 hours after etomidate/thiopentone/propofol induction in diabetic patients and etomidate induction in non diabetic patients respectivelyTimepoint: at 4 hours after induction—

Secondary

MeasureTime frame
1..to compare S. cortisol levels at 24 hours after etomidate/thiopentone/ propofol induction in diabetic patients and etomidate induction in non-diabetic patients respectively 2. ? to evaluate the blood sugar levels baseline, 4 hr, 8 hr, 12 hr, 24 hr with etomidate/thiopentone/propofol induction in diabetic patients and etomidate induction in non diabetic patients respectively . Timepoint: 1S.Cortisol at 24 hours after induction 2. blood sugar levels baseline, 4 hr, 8 hr, 12 hr, 24 hr after induction—

Countries

India

Contacts

Public ContactDr Indira Gurajala

Nizams Institute of Medical Sciences Hyyderabad: Pincode: 500082

indiradevraj@yahoo.co.in7729932044

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026