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Effect of blood saving methods on blood loss in open heart operations

Effect of Acute Normovolemic Haemodilution, Retrograde Autologous Priming and Antifibrinolytic Therapy Applied as Multimodal Blood Conservation Strategy on Perioperative Blood Loss in Cardiac Surgery- A Randomized Control Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/075917
Enrollment
150
Registered
2024-10-25
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery

Interventions

Intervention1: 1)use of tranexamic acid as antifibrinolytic agent 2)acute normovolemic hemodilution 3)retrograde autologous priming 4)heparin and protamine dosing based on heparin protamine dose respo

Sponsors

Jawaharlal Nehru Medical College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age more than 18 years and less than 80 years weight more than 40kgs preoperative hematocrit more than 30% autologous blood will be withdrawn when hematocrit more than 40%

Exclusion criteria

Exclusion criteria: Pediatric cardiac surgeries Bleeding disorders Contraindications to tranexamic acid Serum creatinine more than 1.2mg/dl

Design outcomes

Primary

MeasureTime frame
To compare the effect of multiomodal blood conservation strategy applied during cardiac surgery requiring cardiopulmonary bypass on perioperative blood loss ,allogenic blood transfusion requiremnt and postoperative clinical outcomesTo compare the effect of multiomodal blood conservation strategy applied during cardiac surgery requiring cardiopulmonary bypass on perioperative blood loss ,allogenic blood transfusion requiremnt and postoperative clinical outcomesTimepoint: 7 days—

Secondary

MeasureTime frame
TO COMPARE THE COST EFFECTIVENESS OF MULTIMODAL BLOOD CONSERVATION STRATEGY IN THE PERIOPERATIVE PERIOD DURING CARDIAC SURGERYTimepoint: 10 days—

Countries

India

Contacts

Public ContactDr Rajesh Munigial

Jawaharlal Nehru Medical college

jeet.fortune2013@gmail.com8105155841

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026