Health Condition 1: I251- Atherosclerotic heart disease of native coronary artery
Conditions
Interventions
Control Intervention1: NIL: NIL
Sponsors
Mahatma Gandhi medical college and research institute, Pondicherry
Eligibility
Inclusion criteria
Inclusion criteria: Written informed consent Age more than 18 years Elective off-pump coronary artery bypass graft surgery Preoperative hemoglobin more than or equal to 10 g/dl Central venous saturation-ScvO2 more than or equal to 70% American Society of Anaesthesiology -ASA Grade 2, 3 and 4
Exclusion criteria
Exclusion criteria: Left ventricular ejection fraction of less than 35% Unstable angina pectoris Heart failure with New York Heart Association class III-IV Acute myocardial infarction within the last 2 weeks Previous CABG surgery Patients with chronic obstructive pulmonary disease On-table conversion to Cardiopulmonary bypass surgery known uncorrected valvular incompetence or intracardiac shunting
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To calculate DeltaPCO2 gap / AVO2 content difference ratio around the time of Obtuse marginal artery distal anastomosis during off-pump coronary artery bypass graftingTimepoint: As a baseline after inserting central venous and arterial access under local anesthesia-T0 Just prior to skin incision-T1 Next will be 5 min after flow to LAD has been established-T2 Subsequently 5 min after the distal anastomosis to OM and settling the heart into its normal anatomical position -T3 The mixed venous sample at T2 and T3 will be taken by the operating surgeon, from the main pulmonary artery through a purse-string suture for safety. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To calculate DeltaPCO2 gap PaCO2 – PcvO2, to analyze its correlation with tissue ischemia. 2. To analyze the comparability of using central venous and mixed venous partial pressure of CO2, DeltaPCO2 gap (PaCO2 – PcvO2) and DeltaPCO2 gap /C(a-cv)O2 ratio. Timepoint: As a baseline after inserting central venous and arterial access under local anesthesia-T0 Just prior to skin incision-T1 Next will be 5 min after flow to LAD has been established-T2 Subsequently 5 min after the distal anastomosis to OM and settling the heart into its normal anatomical position -T3 The mixed venous sample at T2 and T3 will be taken by the operating surgeon, from the main pulmonary artery through a purse-string suture for safety. | — |
Countries
India
Contacts
Public ContactDr Anity Singh
Mahatma Gandhi medical college and research institute
Outcome results
None listed