Health Condition 1: G14- Postpolio syndrome
Conditions
Interventions
Intervention1: High Frequency rTMS: Magnetic stimulation will be provided using Neurosoft MS/MD stimulator with angulated figure of 8 coil to Post-Polio Syndrome patients. Each patient will receive st
Sponsors
All India Institute of Medical Sciences, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Inclusion Criteria (for Post polio syndrome patients): 1. Participants diagnosed with post-polio syndrome (PPS) as per EFNS (European Federation of Neurological Societies) guideline proposed by Farbu et. al in 2006. It is based on Halsteadâ??s definition from 1991 with emphasis on the new muscle weakness. We preferred this criterion as Pastuszak et. al. and Acler et. al have used the same in their studies. Diagnosis of PPS is clinical and of exclusion. The EFNS criteria includes: o Confirmed history of polio, o Partially or fairly complete neurological and functional recovery after the acute episode, o Period of at least 15 years with neurological and functional stability, o Gradual or abrupt onset of new neurogenic weakness with or without generalised fatigue, muscle atrophy, muscle joint pain, functional loss, cold intolerance. o No other medical explanation found 2. Age: 25-80 years of any gender Inclusion Criteria (for healthy participants) 1. Age matched healthy volunteers
Exclusion criteria
Exclusion criteria: Exclusion criteria (for post-polio Syndrome patients) 1. All other treatable conditions causing muscle fatigue, wasting, generalised fatigue, muscle atrophy, muscle joint pain, functional loss, cold intolerance. 2. Myopathies of any other origin 3. Any other motor neuron disorders 4. Not able to perform hand movements 5. Known hypersensitivity to electrode materials 6. Psychiatric disorders 7. Pregnancy and Lactation 8. History/ family history of seizures 9. Cardiac Pacemaker or any ferromagnetic metallic implants close to target of stimulation area 10. Acute eczema/ bed sore under target of stimulation area 11. Ventilator dependent and tracheostomy patients 12. Not able to understand the language of Informed consent. 13. Not allowing consent for study participation Exclusion Criteria (for healthy participants) 1. Not able to perform hand movements 2. Known hypersensitivity to electrode materials 3. Pregnancy and Lactation 4. History/ family history of seizures 5. Cardiac Pacemaker or any ferromagnetic metallic implants close to target of stimulation area 6. Ventilator dependent and tracheostomy patients 7. Not able to understand the language of Informed consent. 8. Not allowing consent for study participation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Bereitschaftspotential (onset) Timepoint: Pre-intervention (baseline) and post-intervention (4 weeks after baseline) | — |
Secondary
| Measure | Time frame |
|---|---|
| Bereitschaftspotential (onset & area under curve), EMG changes, EEG EMG coherence & muscle tissue oxygenation measured by NIRS, & adverse events. Fatigue severity scale(FSS), Patient Health Questionnaire-9 (PHQ-9), Epworth sleepiness scale (ESS), World Health Organization Quality of life BREF(WHOQOL-BREF), & VAS for pain.Timepoint: All assessments will be done pre-treatment (baseline) & post-last treatment. FSS, PHQ-9, ESS, WHOQOL-BREF, VAS for pain & systemic examination will also be followed up after 3 months of last treatment. | — |
Countries
India
Contacts
Public ContactDr. Gita Handa
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed