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comparing Oral Methadone and Oral Morphine for Cancer Pain

Comparison of Oral Methadone versus Morphine As a First- Line Strong Opioid for Cancer Pain: A Randomized Double -Blind study - NIL

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/075826
Enrollment
46
Registered
2024-10-24
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-D49- Neoplasms

Interventions

Intervention1: Oral Methadone: Patients in the methadone group will be supplied with tablets containing 5 mg of methadone. The dose consisted of 1/2 to 4 methadone tablets taken twice daily, every 12

Sponsors

Dr Varshali Keniya
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: All ages between 18 and 70 years Cancer patients Numerical Rating Score (NRS) for pain more than or equal to 5 Edmonton Classification System for Cancer Pain (ECS CP) Showing Ne (NEUROPATHIC and NOCIPECTIVE) Willing for informed consent

Exclusion criteria

Exclusion criteria: Patient’s refusal to participate in the study Patient not mentally competent to report From far places who cannot be followed up Patient with cardiac issues, abnormal baseline ECG and documented arrhythmias

Design outcomes

Primary

MeasureTime frame
To compare effectiveness of oral Methadone versus oral Morphine in cancer patient using an 11- point NRS and ESC -CP score in reducing pain in cancer patientTimepoint: 0,7th,14th,21th,28th,35th,42th days

Secondary

MeasureTime frame
To compare- 1. Cost effectiveness of Methadone vs Morphine. 2. Side effects of Methadone vs Morphine. 3. Opioid escalation index.Timepoint: 0,7,14,21,28,35,42 day

Countries

India

Contacts

Public ContactDr Samreen Shaikh

Bharati Vidyapeeth(Deemed to be University) Medical College, Pune

varshali.keniya@bharatividyapeeth.edu9881419089

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026