To find which drug will benefit most for pain control in patient undergoing major abdominal cancer surgeries

Comparitive study between dexmedetomidine and fentanyl as adjuvants to continuous ropivacaine epidural infusion for post-operative analgesia in abdominal cancer surgeries - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075747

Enrollment

Registered

2024-10-23

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Thoracic epidural analgesia with Ropivacaine and Dexmedetomedine in major abdominal cancer surgeries: Comparision between intervention group that is epidural infusion of 0.125% ropivaca

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient scheduled for major abdominal cancer surgeries 2. ASA grade I-III women 3. Age group 18 -70 years 4. BMI = 35

Exclusion criteria

Exclusion criteria: 1. Infection at epidural site 2. History of coagulopathy 3. Severely hypovolemic patients 4. Raised ICP 5. Sepsis 6. Refusal for epidural analgesia 7. Pre-existing neurological deficit or demyelinating disorders 8. Severe spinal deformity 9. Known allergy to local anaesthetics or fentanyl or dexmedetomedine 10. Chronic pain or long term opiods or NSAIDS usage 11. Those who have coexisting cardio-respiratory disease e.g. ventricular dysfunction or history of AV Block /bradyarrythmias 12. Catheter removal unintentionally 13. Asymmetric or unilateral block requiring catheter manipulation 14. Patient not extubated and transferred to ICU 15. Surgery with blood loss more than 30%

Design outcomes

Primary

Measure	Time frame
1. To compare the efficacy and duration of post operative epidural analgesia between the two groups using VAS score at rest and movement 2. To compare cumulative consumption of rescue analgesia between the two groupsTimepoint: 48 hours	—

Secondary

Measure	Time frame
To compare time to first rescue analgesia requirement between the two groupsTimepoint: 48 hours;To compare incidence of such as bradycardia, hypotension and sedation, post-operative ileus and nausea & vomiting between two groupsTimepoint: 48 hours	—

Countries

India

Contacts

Public ContactDr Mathilda Behera

Indira Gandhi Medical college, shimla

aparnasharmaraina@gmail.com9418083224

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026