Comparing Two Materials to Help Heal the bone After Removing Wisdom Teeth of lower jaw

Comparison of efficacy of intra-socket application of Nano Hydroxyapatite with Hyaluronic Acid and Collagen as graft material after surgical removal of impacted mandibular 3rd molar - A Randomized Split-Mouth Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075745

Enrollment

Registered

2024-10-23

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: hydroxyapatite with hyaluronic acid graft material: G bone - Hydroxyapatite with 2% hyaluronic acid will be mixed together chairside after extraction hyaluronic acid comes in solg

Eligibility

Inclusion criteria

Inclusion criteria: ASA class 1 patient . Age 18-40 years. Bilateral similar impacted mandibular third molars.

Exclusion criteria

Exclusion criteria: Patients with any bony pathologies. Patients with any hormonal imbalance which affects bone healing. Patients on corticosteroids or oral contraceptives. Pregnant and lactating mothers. Patient allergic to any of the graft materials used in this study. Patients with history of deleterious habits such as alcohol consumption, smoking, etc.

Design outcomes

Primary

Measure	Time frame
Evaluate the efficacy of hydroxyapatite with hyaluronic acid on postoperative pain and swelling after third molar removal. Assess the effect of hyaluronic acid on trismus after third molar extraction. Compare wound healing and bone density after using hydroxyapatite with collagen or hyaluronic acid grafts post-mandibular third molar extractionTimepoint: Compare pain using the Visual Analog Scale on the 1st, 7th, and 15th postoperative days after each extraction on the same patient. Measure swelling using gonion-lateral canthus and tragus-angle of mouth distances on the 1st, 7th, and 15th postoperative days. Assess wound healing using Landrys Index on the 1st, 7th, and 15th postoperative days. Evaluate mouth opening or trismus on the 1st, 7th, and 15th postoperative days. Take OPG on the 30th day post-op to assess bone density.	—

Measure

Time frame

Evaluate the efficacy of hydroxyapatite with hyaluronic acid on postoperative pain and swelling after third molar removal. Assess the effect of hyaluronic acid on trismus after third molar extraction. Compare wound healing and bone density after using hydroxyapatite with collagen or hyaluronic acid grafts post-mandibular third molar extractionTimepoint: Compare pain using the Visual Analog Scale on the 1st, 7th, and 15th postoperative days after each extraction on the same patient. Measure swelling using gonion-lateral canthus and tragus-angle of mouth distances on the 1st, 7th, and 15th postoperative days. Assess wound healing using Landrys Index on the 1st, 7th, and 15th postoperative days. Evaluate mouth opening or trismus on the 1st, 7th, and 15th postoperative days. Take OPG on the 30th day post-op to assess bone density.

—

Secondary

Measure	Time frame
To assess a better morbidity & decrease of post op complications by fore said parametersTimepoint: follow up after 1, 7, 15 for measuring pain, swelling, mouth opening & wound healing after each extraction follow up after 1 month of each extraction for OPG xray	—

Countries

India

Contacts

Public ContactDr Arvind Rao HT

Yenepoya Dental college

arvind_raoht@rediffmail.com9448142508

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026