To compare the attenuation of hemodynamic response during laryngoscopy and suppression of stress response during laproscopic cholecystectomy surgery in patients who are premedicated with oral clonidine versus oral atenolol

Attenuation of hemodynamic response of laryngoscopy and suppression of stress response during laproscopic cholecystectomy in patients premedicated with oral clonidine versus oral atenolol:A Prospective Randomised Placebo Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075725

Enrollment

156

Registered

2024-10-23

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: K801- Calculus of gallbladder with othercholecystitis

Interventions

Intervention1: To compare the attenuation of hemodynamic response to laryngoscopy and suppression of stress response during laproscopic cholecystectomy in patients premedicated with oral clonidine ver

Eligibility

Inclusion criteria

Inclusion criteria: ASA I & ASA II, normotensive patients undergoing laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: ASA III & IV , Hypersensitivity to Atenolol or clonidine SBP less than 100 mmhg heart rate less than 60 per min & more than 120 per min recent myocardial infarction coronary artery disease conduction defect obstructive airway disease second or third degree heart block patient already on antihypertensive medication

Design outcomes

Primary

Measure	Time frame
To compare perioperative hemodynamic changes in heart rate and blood pressure To compare the requirement of additional beta blockersTimepoint: Perioperative changes in heart rate and blood pressure will be monitored at baseline, at the time of receiving drug, when patient is shifted to OT, at intubation and then at 3 minute intervals till 15 minutes post intubation, then at every 15 minutes till extubation.	—

Measure

Time frame

To compare perioperative hemodynamic changes in heart rate and blood pressure To compare the requirement of additional beta blockersTimepoint: Perioperative changes in heart rate and blood pressure will be monitored at baseline, at the time of receiving drug, when patient is shifted to OT, at intubation and then at 3 minute intervals till 15 minutes post intubation, then at every 15 minutes till extubation.

—

Secondary

Measure	Time frame
To compare postoperative recovery To compare postoperative nausea and vomiting To study post operative pain scores and total dose of rescue analgesiaTimepoint: 1 hour 4 hour 8 hour 12 hour 16 hour 20 hour 24 hour	—

Countries

India

Contacts

Public ContactDr Nitesh Sinha

Rajendra Institute of Medical Sciences

ekramrims@yahoo.co.in9431101186

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026