Dexmedetomidine vs Magnesium sulfate in blood pressure and heart rate control in patients undergoing laparoscopic surgery for gall bladder removal

Effect of Magnesium sulfate and Dexmedetomidine on hemodynamic perturbations,anesthetic requirements and recovery profile in adult patients undergoing Laparoscopic cholecystectomy-A prospective double blind randomized study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075661

Enrollment

Registered

2024-10-23

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K802- Calculus of gallbladder without cholecystitis

Interventions

Intervention1: Intravenous Magnesium Sulfate: Group M-Magnesium sulfate 12ml(6000mg) and 8ml 0.9% normal saline(300mg/1ml) given as 0.4ml/kg/hr for 15 minutes as bolus followed by 0.03ml/kg/hr infusio

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age:18-65 years 2.ASA Physical status 1 and 2

Exclusion criteria

Exclusion criteria: 1.Patients with hypermagnesemia 2.Patients with heart blocks or arrythmias 3.Patients allergic to study drugs and addicted to narcotics 4.Patients with chronic liver/renal/cardiovascular diseases 5.Patients who are on beta blockers 6.Surgeries which lasts for more than 4 hours

Design outcomes

Primary

Measure	Time frame
To compare the effect of Magnesium sulfate and Dexmedetomidine on hemodynamic perturbations following pneumoperitoneum during laparoscopic cholecystectomyTimepoint: T4-Before pneumoperitoneum T5-1 min after pneumoperitoneum T6-5 min after pneumoperitoneum T7-15 min after pneumoperitoneum T8-30 min after pneumoperitoneum T9-After release of pneumperitoneum	—

Secondary

Measure	Time frame
To compare the effect of magnesium sulfate and dexmedetomidine on hemodynamic perturbations following laryngoscopy and intubationTimepoint: T0-Base line T1-Before induction T2-1 min after intubation T3-5 min after intubation;To compare the effect of study drugs on intraoperative anesthetic requirement(propofol and fentanyl)Timepoint: Throughout intraoperative period;To compare the effect of study drugs on postoperative recovery profile (extubation,eye opening and recovery times and NRSTimepoint: T10-1 min after extubation T11-15 min after extubation T12-60 min after extubation Extubation time Eye opening time Recovery time NRS score-15 min post extubation NRS score-60 min post extubation	—

Measure

Time frame

To compare the effect of magnesium sulfate and dexmedetomidine on hemodynamic perturbations following laryngoscopy and intubationTimepoint: T0-Base line T1-Before induction T2-1 min after intubation T3-5 min after intubation;To compare the effect of study drugs on intraoperative anesthetic requirement(propofol and fentanyl)Timepoint: Throughout intraoperative period;To compare the effect of study drugs on postoperative recovery profile (extubation,eye opening and recovery times and NRSTimepoint: T10-1 min after extubation T11-15 min after extubation T12-60 min after extubation Extubation time Eye opening time Recovery time NRS score-15 min post extubation NRS score-60 min post extubation

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Countries

India

Contacts

Public ContactDr S R A N Bhushanam Padala

All India Institute Of Medical Science,Bhopal

padala72@gmail.com7893562302

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026