Health Condition 1: C729- Malignant neoplasm of central nervous system, unspecified
Conditions
Interventions
Intervention1: Radiotherapy: Adaptive radiotherapy will be delivered based on interval imaging using MRI and PET. Fractionated radiotherapy will continue on daily basis, 5 days a week, for a duration
Sponsors
Tata Memorial Centre
Eligibility
Inclusion criteria
Inclusion criteria: 1.Histological diagnosis of diffuse glioma. Patients with IDH-negative GBM (stratum A) and IDH-mutant glioma (astrocytoma or oligodendroglioma) needing radiotherapy (stratum B). 2. Age: 18-70 years. 3.Karnofsky Performance Scale (KPS) >=60
Exclusion criteria
Exclusion criteria: Multifocal or multicentric disease • Not eligible for radical intent radiation. • IDH status unknown or uninterpretable (IHC or gene sequencing). • Use of prior radiotherapy to the head-neck region or brain or chemotherapy. • Contraindication/unable to undergo MRI or PET scan during radiation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Proportion of patients undergoing volumetric and biological adaptation. â?¢ Cumulative rate of symptomatic radionecrosis (RN) at 2 years.Timepoint: Cumulative rate of symptomatic radionecrosis (RN) at 2 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| Progression free survival,Overall survivalTimepoint: 4 years | — |
Countries
India
Contacts
Public ContactDr Archya Dasgupta
Tata Memorial Centre,Mumbai
Outcome results
None listed