Comparing the recovery between patients receiving Ketamine-Dexmedetomidine infusion versus Fentanyl- Dexmedetomidine infusion during the surgery

Recovery profile of intraoperative Ketamine-Dexmedetomidine infusion versus Fentanyl- Dexmedetomidine infusion in patients undergoing General anaesthesia - A Randomised control study - Nil

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075583

Enrollment

Registered

2024-10-21

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS- Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Ketamine-Dexmedetomidine infusion versus Fentanyl- Dexmedetomidine infusion: Group A: DK Group -IV Dexmedetomidine(0.5 ug /kg/h)+Ketamine (0.5 mg/kg/h) Group B: DF Group - IV Dexmedetom

and also measured after extubation, 5,10,15 mins after extubation.Duration of intervention is from the time of intubation to the time of skin closure. Control Intervention1: Ketamine-Dexmedetomidine i

and also measured after extubation, 5,10,15 mins after extuba

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 and 2 patients of either sex from 18-60 years of age undergoing major abdominal or head and neck surgeries.

Exclusion criteria

Exclusion criteria: Patient refusal American Society of Anesthesiology Class 3 and more Known drug allergy Heart block Arrhythmias Respiratory disorder Renal & Hepatic dysfunction

Design outcomes

Primary

Measure	Time frame
To compare the recovery profile between the two groups.ketamine(0.5mg/kg/hr)and dexmedetomidine(0.5mcg/kg/hr) & fentanyl( 0.5mcg/kr/hr) and dexmedetomidine(0.5mcg/kg/hr) in the patients aged between 18 to 60 years undergoing general anesthesiaTimepoint: 0mins,5mins,10mins,15mins,20mins,25mins,30mins,45mins,60mins,75mins,90mins,105mins,120mins after extubation 5mins,10mins,15mins	—

Secondary

Measure	Time frame
to compare the hemodynamic parameters between the two groups.ketamine(0.5mg/kg/hr)and dexmedetomidine(0.5mcg/kg/hr) & fentanyl( 0.5mcg/kr/hr) and dexmedetomidine(0.5mcg/kg/hr) in the patients aged between 18 to 60 years undergoing general anesthesiaTimepoint: 0mins,5mins,10mins,15mins,20mins,25mins,30mins,45mins,60mins,75mins,90mins,105mins,120mins after extubation 5mins,10mins,15mins	—

Countries

India

Contacts

Public ContactUthayasankar

Sri Venkateshwaraa Medical College Hospital and Research Centre, Puducherry

sujathachinthavali@gmail.com8939012490

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026