Health Condition 1: K041- Necrosis of pulp
Conditions
Interventions
Intervention1: experimental scaffold: teeth in the experimental group will receive the scaffold of Fibrin glue loaded with E- nanoHA seeded with SHED
Control Intervention1: blood clot scaffold with MT
Sponsors
Indian Council of Medical Research
Eligibility
Inclusion criteria
Inclusion criteria: 1. Fractured maxillary anterior tooth presenting with symptoms of irreversible pulpitis 2. Tooth with radiographic presence of open apex (Nolla’s stages 7 and 8) 3. Radiographic evidence of apical periodontits (Ostravik’s score 3 and above) 4. Tooth testing negative for pulp vitality (Pulpal blood flow) testing using laser speckled contrast imaging system.
Exclusion criteria
Exclusion criteria: 1. Patients not willing to take part in the study 2. Tooth with extensive fracture of crown in which rubber dam clamp cannot be placed 3. Tooth with crown-root fracture/ root fracture 4. Clinical or radiographic presence of alveolar/ maxillofacial bone fractures 5. Tooth presenting with grade II or grade III mobility 6. Patients with known allergy to medicaments used in the study 7. Medically compromised patients with co-existing systemic/ immunocompromised conditions
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Positive response to pulp vitality, radiographic increase in root length, increased radicular dentin thickness and reduction in apical diameter would be considered as primary outcomeTimepoint: a baseline evaluation of teh variables will be recorded and effects of the intervention will be assessed 1, 3, 6, 12, 18 and 24 months after completion of the treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| nilTimepoint: nil | — |
Countries
India
Contacts
Public ContactDr. J. Shanti Swarup
Tamil Nadu Government Dental College and Hospital
Outcome results
None listed