Comparison of tissue perfusion using difference in partial pressure of venous and arterial Carbon dioxide during Sevoflurane Inhalation (anaesthetic agent) versus Propofol (anaesthetic agent) Infusion for maintenance of Anaesthesia in elective Off-Pump Coronary Artery Bypass Grafting surgery

Comparison of tissue perfusion using difference in partial pressure of venous and arterial Carbon dioxide difference during Sevoflurane inhalation versus propofol Infusion for maintenance of Anaesthesia In elective off-pump Coronary Artery Bypass Grafting surgery - NIL

Status

Recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075524

Enrollment

Registered

2024-10-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-02-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Propofol infusion: Injection propofol will be given at a dose of 50-150 mcg/ kg/min in the form of infusion during elective off-pump coronary artery bypass grafting surgery for maintena

Eligibility

Inclusion criteria

Inclusion criteria: Adult patients (40 to 80 years of age), Both sex, American Society of Anesthesiology (ASA- II, III, Elective OPCABG surgery.

Exclusion criteria

Exclusion criteria: Patients with left ventricular ejection fraction less than 30%, Patients with history of severe hepatic, renal dysfunction, Chronic obstructive pulmonary disease (COPD) with FEV1 less than 50%, PaCO2 more than 60mmHg, Patients undergoing combined surgical procedures (CABG combined with valve surgery aortic procedure, and carotid surgery), Redo surgeries, Patients with sepsis and septic shock, Emergency CABG, Off- pump CABG converted to on pump, Patients with serum lactate more than 3.0 mmol/L preoperatively, Patients with associated valvular heart disease, Symptomatic peripheral artery disease, Pregnant patients, Patient refusal

Design outcomes

Primary

Measure	Time frame
1.To compare tissue perfusion between the two groups by calculation of the difference in the partial pressure of carbon dioxide in arterial, central, and mixed venous samples, 2.To correlate the above with serum lactate levels.Timepoint: T0 (post induction).T1(2 hours post induction), T2 (4 hours post induction) and thereafter in post-operative ICU at T3 (3 hours post operatively), T4 (6 hours post operatively), T5 (18 hours postoperatively), T6 (24 hours postoperatively), T7 (48 hours postoperatively	—

Measure

Time frame

1.To compare tissue perfusion between the two groups by calculation of the difference in the partial pressure of carbon dioxide in arterial, central, and mixed venous samples, 2.To correlate the above with serum lactate levels.Timepoint: T0 (post induction).T1(2 hours post induction), T2 (4 hours post induction) and thereafter in post-operative ICU at T3 (3 hours post operatively), T4 (6 hours post operatively), T5 (18 hours postoperatively), T6 (24 hours postoperatively), T7 (48 hours postoperatively

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Secondary

Measure	Time frame
1. To measure cardiac output and pulmonary artery catheter (PAC) derived parameters via thermodilution technique using cold saline injectate 2. To compare changes in haemodynamic variables (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, central venous pressure) during intraoperative period in both the groups 3. To calculate the Vasoactive-Inotropic Score (VIS) 4. To compare the length of ICU stay 5. Complications / adverse events (if any)Timepoint: T0 (post induction).T1(2 hours post induction), T2 (4 hours post induction) and thereafter in post-operative ICU at T3 (3 hours post operatively), T4 (6 hours post operatively), T5 (18 hours postoperatively), T6 (24 hours postoperatively), T7 (48 hours postoperatively)	—

Measure

Time frame

1. To measure cardiac output and pulmonary artery catheter (PAC) derived parameters via thermodilution technique using cold saline injectate 2. To compare changes in haemodynamic variables (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure, central venous pressure) during intraoperative period in both the groups 3. To calculate the Vasoactive-Inotropic Score (VIS) 4. To compare the length of ICU stay 5. Complications / adverse events (if any)Timepoint: T0 (post induction).T1(2 hours post induction), T2 (4 hours post induction) and thereafter in post-operative ICU at T3 (3 hours post operatively), T4 (6 hours post operatively), T5 (18 hours postoperatively), T6 (24 hours postoperatively), T7 (48 hours postoperatively)

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Countries

India

Contacts

Public ContactIndira Malik

PT . B. D. Sharma PGIMS, Rohtak

mdr.indira@yahoo.in9350224435

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026