A comparison of the therapeutic effects of different methods of vitamin B12 administration—through the nose, muscle injection, and intravenous injection—on blood-related health indicators in individuals with B12 deficiency anemia.

comparing the therapeutic effects of intranasal, intramuscular, intravenous B12 administration on haematological parameters in B12 deficiency anaemia - CHAMPION B12

Status

Recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075521

Enrollment

100

Registered

2024-10-18

Start date

Unknown

Completion date

Unknown

Last updated

2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D510- Vitamin B12 deficiency anemia dueto intrinsic factor deficiency Health Condition 2: D511- Vitamin B12 deficiency anemia dueto selective vitamin B12 malabsorption with proteinuria Health Condition 3: D512- Transcobalamin II deficiency Health Condition 4: D518- Other vitamin B12 deficiency anemias Health Condition 5: D519- Vitamin B12 deficiency anemia, unspecified

Interventions

Intervention1: Nasal B12: Patients diagnosed with B12 deficiency anaemia (based on WHO criteria) will be administered nasal B12 250 micrgrams alternate day for 07 doses followed by weekly dose for 04

Eligibility

Inclusion criteria

Inclusion criteria: All patients diagnosed with B12 deficiency anaemia. Willingness to give consent

Exclusion criteria

Exclusion criteria: 1. Pregnant females 2. All other causes of anaemia 3. Requiring blood transfusion at initiation of therapy

Design outcomes

Primary

Measure	Time frame
COMPARE THE CHANGE IN HEMATOLOGICAL PARAMETERS (HAEMOGLOBIN, MEAN CORPUSCULAR VOLUME)Timepoint: COMPARE THE CHANGE IN HEMATOLOGICAL PARAMETERS (HAEMOGLOBIN, MEAN CORPUSCULAR VOLUME) ON DAY 14 AND DAY 28 IN EACH GROUP (INTRAVENOUS, INTRAMSCULAR AND NASAL B12 TREATMENT AS PER ESTABLISHED GUIDELINES)	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactRahil Arora

Armed Forces Medical College

rahilarora1992@gmail.com7986067569

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jul 4, 2026