Health Condition 1: R652- Severe sepsis
Conditions
Interventions
Intervention1: Continuous non-invasive cardiac output monitor: The subjects randomized to the intervention arm will be connected to the portable hand- held continuous non-invasive cardiac output monit
Sponsors
Mounika Reddy
Eligibility
Inclusion criteria
Inclusion criteria: Children aged 2 months to 18 years with early septic shock, defined as children with suspect or confirmed sepsis and unresolved shock or hypoperfusion after the initial 20ml per kg fluid bolus or 1000 ml fluid bolus in patients weighing over 50 kg, received within last 4 hours
Exclusion criteria
Exclusion criteria: Exclusion criteria: - Preterm babies with corrected age less than 2 months - Children with fulminant myocarditis or cardiomyopathy - Children with unrepaired congenital heart disease or cardiac failure - Children with severe acute malnutrition - Known chronic renal failure defined as requiring renal replacement therapy - Known chronic hepatic failure - Already on inotropes for more than 2 hours - Suffered cardiorespiratory arrest within less than 2 hours requiring cardiopulmonary resuscitation of more than 2 mins duration - Moribund patients with anticipated survival less than 24 hrs - Not willing to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the difference between the two groups in terms of survival free of organ dysfunctionTimepoint: At 28 days | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to achieve therapeutic end-points of shock resolutionTimepoint: till discharge;Fluid overload percentageTimepoint: 24, 48 and 72 hours;Length of PICU stay and hospital stayTimepoint: till discharge;Early and late mortalityTimepoint: 7 and 28 day;Physiological markers including lactate - Inotropes, ventilation, other organ supportTimepoint: till discharge | — |
Countries
India
Contacts
Public ContactDr Mounika Vadhi Reddy
All India Institute of Medical Sciences Bibinagar
Outcome results
None listed