To compare the differences in outcome between a preset positive pressure and standard(zero positive pressure) during Chest compressions in patients with cardiac arrest

PEEP VS ZEEP In cardiopulmonary resuscitation A randomised controlled pilot trial - NIL

Status

Active, not recruiting

Phases

Phase 1Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075484

Enrollment

Registered

2024-10-18

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I469- Cardiac arrest, cause unspecified

Interventions

Intervention1: PEEP of 5cm of water: in patients presenting with cardiac arrest and randomised to the intervention group, CPR will be given with a PEEP of 5cm H2O till the achievement of ROSC (return

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients with cardiac arrest 2.Legally authorised representative willing to give valid consent

Exclusion criteria

Exclusion criteria: 1.Legally authorised representative unwilling to give consent 2.Patients less than 18 years of age 3.Patients requiring surgical airway 4.patients with obstructive airway disease 5.patients with history of trauma 6.pregnant women 7.patients with metastatic cancer

Design outcomes

Primary

Measure	Time frame
To compare the rates to ROSC (return of spontaneous circulation) in patients receiving zero PEEP versus PEEP (5cm H2O) during CPR in cardiac arrestTimepoint: at achievement of ROSC or at maximum 40mins of CPR	—

Secondary

Measure	Time frame
1.To compare the PCo2 clearance Timepoint: At achievement of ROSC or 40minutes;2.Ventilation related complicationTimepoint: During the course of CPR;3.24 hour survival ratesTimepoint: At 24 hours ( if applicable);Neurological outcomesTimepoint: At discharge	—

Countries

India

Contacts

Public ContactDr Ashwin Kumar

AIIMS, New Delhi

jamshednayer@gmail.com9990345682

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026