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To compare the how well clonidine and gabapentin given orally as premedication, reduces changes in blood pressure and heart rate during laryngoscopy and tracheal intubation.

A comparative study of clonidine and gabapentin as an oral premedication on hemodynamic response to laryngoscopy and tracheal intubation - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/075366
Enrollment
32
Registered
2024-10-16
Start date
Unknown
Completion date
Unknown
Last updated
2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Tablet clonidine 0.2mg: Tablet clonidine 0.2mg given as oral premedication 30 minutes before laryngoscopy and tracheal intubation for attenuating exaggerated hemodynamic response . Cont

Sponsors

Smt Bhikiben Kanjibhai Shah Medical Institute and Research Centre
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: •Patients will be willing to sign written and informed consent. •Male or female patients between 18 to 60 years of age. •Patients will belonging to American Society of Anaesthesiologists (ASA) physical status I and II. •Patients will be posted for elective surgeries under general anaesthesia.

Exclusion criteria

Exclusion criteria: •Patients unwilling to participate in the study. •Patients with Body Mass Index >= 30 kg/m2. •Patients with history of muscular disorder ; myositis, myoclonus, myasthenia gravis. •Patients with cardiovascular diseases, arrhythmias, heart blocks, or taking beta blockers. •Patients with cerebrovascular, hepatic and renal diseases. •Psychiatric patients. •Patients will blur vision •Patients with history of allergy to an α-2 adrenergic agonist •Pregnancy & lactating women.

Design outcomes

Primary

MeasureTime frame
To compare tablet clonidine and gabapentin as given oral premedication premedication , in attenuating exaggerated hemodynamic response during laryngoscopy and tracheal intubation.Timepoint: Baseline vitals(HR ,SBP ,DBP,MAP) After Test drug administration After induction At laryngo- scopy and intubation After Intubation (In minutes) 1 min,3 min,5 min,7min,10min—

Secondary

MeasureTime frame
Check for analgesic ,opioids requirement.Timepoint: During laryngoscopy and tracheal intubation and until 10 minutes after it.—

Countries

India

Contacts

Public ContactTejash H Sharma

Smt. Bhikiben Kanjibhai Shah Medical Institute and Research Centre

drtejash@gmail.com9427332100

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026