Health Condition 1: O- Medical and Surgical Health Condition 2: I01- Rheumatic fever with heart involvement
Conditions
Interventions
Intervention1: Dexmedetomidne at 05 ug/kg/hr: This was the adjuvant sedative given in these patients.
This will be given INTRAVENOUSLY, at 5ug/kg/hr. This will be given from the onset of induction of
Sponsors
Dr Sanjeeta Umbarkar
Eligibility
Inclusion criteria
Inclusion criteria: Patients undergoing valvular cardiac surgery
Exclusion criteria
Exclusion criteria: Preoperative treatment with morphine or its derivatives including tramadol in the 15 days preceding the inclusion visit Pre-existing high-degree conduction disorder Oxygen therapy prior to inclusion Heart failure with LVEF less than 40 percent BMI more than 35 Myocardial suffering in the 5 days preceding surgery Patient in shock Known adrenal insufficiency and or long-term systemic corticosteroid treatment equivalent to hydrocortisone hemisuccinate more than 20 mg per day Long-term non-invasive ventilation including for obstructive sleep apnea syndrome Any antecedent or active practices of drug addiction Contraindication to one of the experimental and or nonexperimental treatment like dexmedetomidine lidocaine dexamethasone ketamine remifentanil or morphine Acute cerebrovascular pathology Severe hepatic insufficiency with factor V level less than 50 percent Pre-existing cognitive disorders Pregnant or parturient or breastfeeding woman Person deprived of liberty by an administrative or judicial decision or person placed under judicial protection under guardianship or guardianship Patient participating in another drug trial or having participated in another drug trial within 1 month before randomization
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To assess the effects of Dexmedetomidine on hemodynamics and depth of anesthesia in patients undergoing valvular heart replacement surgeriesTimepoint: Baseline post induction after Sternotomy after pericardiotomy 5 minutes after protamine administration end of surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| To assess duration of ICU stay & incidences of postoperative complications which received Dexmedetomidine perioperativelyTimepoint: Admission to ICU after surgery upto 30 days status of patient | — |
Countries
India
Contacts
Public ContactDr Sanjeeta Umbarkar
Seth GS Medical college and KEM Hospital
Outcome results
None listed