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Comparing two doses of Dexamethasone to prevent low blood pressure after Spinal Anaesthesia: A Clinical Study

Comparison of Two Different Doses of Dexamethasone for Attenuation of Post Spinal Anaesthesia Hypotension: A Prospective, Randomized, Double-blind, Clinical Study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/075326
Enrollment
184
Registered
2024-10-15
Start date
Unknown
Completion date
Unknown
Last updated
2025-10-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Group D4: Patients will receive Dexamethasone 4 mg diluted in 100 ml 0.9% normal saline (NS) IV infusion over 15 min 2 hours preoperatively Control Intervention1: Group D8: Patients wil

Sponsors

AIIMS Rajkot
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grdae I, II & III patients posted for elective lower abdominal and lower limb surgeries under spinal anesthesia.

Exclusion criteria

Exclusion criteria: Patient refusal Emergency surgery Pregnant patients Any contraindications to spinal anaesthesia Patients on steroids

Design outcomes

Primary

MeasureTime frame
Proportion of patients who developed Post Spinal hypotension (PSH) within 20 minutes of spinal anaesthesia.Timepoint: Mean blood pressure (MBP) will be recorded before giving the study medication (base line) and then after Spinal Anaesthesia every 5 min for 20 minutes.—

Secondary

MeasureTime frame
Severity of Post Spinal hypotension (PSH).Timepoint: After spinal anaesthesia till 6 hours post operative period.;Number of patients requiring ephedrine/atropine.Timepoint: After spinal anaesthesia till 6 hours post operative period.;Total dose of ephedrine required.Timepoint: After Spinal anaesthesia till 6 hours post operative period;Effect on perioperative blood glucose levels. Timepoint: Before giving test drug, then at the interval of 2 hours, 4 hours and 6 hours.;Occurrence of other side effects (nausea/vomiting/shivering).Timepoint: After spinal anaesthesia till 6 hours of post opertive period.—

Countries

India

Contacts

Public ContactKhushboo Pandey

AIIMS Rajkot

khushboo0411@gmail.com9888530182

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026