Health Condition 1: S061- Traumatic cerebral edema
Conditions
Interventions
Intervention1: 3% NaCl: If weight less than 80 kgs, 3% NaCl administered at 100 mL Q6H x 8 doses (2 days) followed by 50 ml Q6H x 4 doses (1 day) and stopped.
If weight more than 80 kgs, 3% NaCl admin
Sponsors
Christian Medical College Vellore
Eligibility
Inclusion criteria
Inclusion criteria: Patients above the age of 18 years admitted following traumatic brain injury requiring osmotherapy.
Exclusion criteria
Exclusion criteria: Patients with serum sodium level less than 135 mmol/L at admission. Patients receiving diuretics or patients with renal failure – AKI/CKD. Patients who require surgery within the first 24 hours of admission. Patients who were primarily managed elsewhere. Patients with bilaterally fixed and non-reactive pupils. Pregnant women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delayed hyponatremia defined as serum sodium dropping below 135 mmol/L after the initiation of osmotherapy and within seven days of trauma.Timepoint: Within seven days of trauma. | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of ICU stay. Duration of hospital stay. Requirement of Fludrocortisone. Need for surgical intervention Development of hyperchloremic metabolic acidosis.Timepoint: Within seven days of trauma. | — |
Countries
India
Contacts
Public ContactMathew Joseph
Christian Medical College, Vellore
Outcome results
None listed