Study to show the effects of Preoperative Lignocaine Nebulization To Reduce Increased Blood Pressure After Laryngoscopy And Tracheal Intubation In Patients Undergoing Surgery Under General Anesthesia

Preoperative Lignocaine Nebulization For Attenuation Of The Pressor Response Of Laryngoscopy And Tracheal Intubation In Patients Undergoing Surgery Under General Anesthesia: A Randomized Control Trial - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075243

Enrollment

Registered

2024-10-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Inj 4% Lignocaine: Pre operative nebulization with 4% Lignocaine in dosage 4mg/kg 10 mins prior to induction for duration 15 mins Control Intervention1: Inj 0.9% Normal saline: Pre oper

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients undergoing elective surgeries under General anesthesia 2. ASA physical status 1 & 2

Exclusion criteria

Exclusion criteria: 1. Patients undergoing emergency surgeries under general anesthesia. 2. Patients undergoing surgery under regional anesthesia. 3. Patients with known allergy to lignocaine. 4. Patients with anticipated airway difficulty. 6. Active smokers 7. Recent URTI within past 2 weeks

Design outcomes

Primary

Measure	Time frame
To compare the effects of nebulised Lignocaine versus nebulised Normal saline on the systolic blood pressure changes in response to laryngoscopy and endotracheal intubation in patients undergoing surgery under General anesthesia with standard induction techniquesTimepoint: Systolic blood pressure readings every 1 minute till 10 minutes after endotracheal intubation	—

Secondary

Measure	Time frame
To compare the effects of nebulised Lignocaine versus nebulised Normal saline on changes in heart rate, blood glucose levels & grade of cough during emergence in response to laryngoscopy & endotracheal intubation in patients undergoing surgery under General anesthesia.Timepoint: Heart rate at every 1 minute till 10 minutes after intubation. Fasting Blood glucose on morning of surgery & blood glucose reading 10 minutes after intubation	—

Measure

Time frame

To compare the effects of nebulised Lignocaine versus nebulised Normal saline on changes in heart rate, blood glucose levels & grade of cough during emergence in response to laryngoscopy & endotracheal intubation in patients undergoing surgery under General anesthesia.Timepoint: Heart rate at every 1 minute till 10 minutes after intubation. Fasting Blood glucose on morning of surgery & blood glucose reading 10 minutes after intubation

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Countries

India

Contacts

Public ContactJ John Magesh Kumar

Armed Forces Medical College

majjohnmk9090@gmail.com9765167438

Outcome results