A Comparative Study of Oral Etoricoxib and Oral Diclofenac for Post-Operative Pain Management Following Laparoscopic Cholecystectomy

Comparison of effectiveness of pre operative administration of oral Etoricoxib and oral Diclofenac on post operative pain relief after laparoscopic cholecystectomy-Randomized, Controlled, Clinical Trial - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075240

Enrollment

Registered

2024-10-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K80- Cholelithiasis

Interventions

Intervention1: pre operative administration of oral Etoricoxib and oral Diclofenac: Etoricoxib 120mg given by oral route one group of participants and Diclofenac 100mg given by oral route to other gr

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA 1 and ASA 2 patients 2.Patient scheduled for laparoscopic cholectectomy 3.Patient between 18 to 60 yrs of age of either sex 4.Written informed consent.

Exclusion criteria

Exclusion criteria: 1.Not giving consent to study 2.ASA grade 3 and 4 3.Pregnant or breastfeeding 4.History of gastrointestinal ulcer or peptic ulcer events 5.Allergy to study drugs 6.Systemic diseases affecting kidneys, liver, blood, or central nervous system

Design outcomes

Primary

Measure	Time frame
A prospective randomized control trial to compare the efficacy of etoricoxib and diclofenac in the management of post operative pain following laparoscopic cholecystectomyTimepoint: primary outcome will be the extent of pain. The intensity of the pain variable will be recorded using a visual analog scale (VAS), ranging from 0 (no pain) to 10 (maximum pain). Each patient will be asked to rate the perceived pain at 1,2,3,4,5, 6, 8, 10,12 and 24 hour post operatively	—

Measure

Time frame

A prospective randomized control trial to compare the efficacy of etoricoxib and diclofenac in the management of post operative pain following laparoscopic cholecystectomyTimepoint: primary outcome will be the extent of pain. The intensity of the pain variable will be recorded using a visual analog scale (VAS), ranging from 0 (no pain) to 10 (maximum pain). Each patient will be asked to rate the perceived pain at 1,2,3,4,5, 6, 8, 10,12 and 24 hour post operatively

—

Secondary

Measure	Time frame
1.To observe the time needed for first rescue analgesia (IV Tramadol). 2.To compare adverse effects between groups 3.To compare total rescue analgesia dose needed between groups in post operative period Timepoint: assessment done at 1,2,3,4,5, 6, 8, 10,12 and 24 hour post operatively	—

Countries

India

Contacts

Public ContactProf S K Mathur

Institute of Medical Sciences BHU

skmathurbhu@gmail.com9450955143

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026