Health Condition 1: G939- Disorder of brain, unspecified
Conditions
Interventions
Intervention1: Sevoflurane: Sevoflurane group: anaesthesia will be maintained with fentanyl 1 µg/kg/h, rocuronium 0.1 mg /kg/h, and sevoflurane (0.8-1 MAC) titrated to a BIS between 40 and 60.
Contro
Sponsors
AIIMS NEW DELHI
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 60, of either gender, belonging to ASA physical status Iâ??II undergoing emergency decompressive craniotomy for traumatic brain injury requiring general anaesthesia.
Exclusion criteria
Exclusion criteria: Patients with mild moderate head injury Patients with SBP less then 90 mmHg Previous history of heart disease or surgery. Hemodynamic instability requiring medical or mechanical attention Severe hepatic and renal insufficiency, and Severe chronic obstructive pulmonary disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the syndecan-1 and Heparan sulfate (HS) levels between sevoflurane and propofol-based anesthesia in moderateâ??toâ??severe Traumatic brain injury (TBI) patients undergoing decompressive craniectomyTimepoint: Starting point-prior to induction of anaesthesia as baseline values, intraoperatively at every 10 min interval till the end of surgery End Point-12 h after completion of surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the effect of the degree of endotheliopathy on the Intensive care unit (ICU) and hospital stay among patients with TBI between sevoflurane and propofol-based anesthesiaTimepoint: Starting point-prior to induction of anaesthesia as baseline values, intraoperatively at every 10 min interval till the end of surgery End Point-12 h after completion of surgery | — |
Countries
India
Contacts
Public ContactDr Niraj Kumar
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed