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Comparing the performance of bp/mp-MRI of prostate, PSMA PET scan and Prostate biopsy in diagnosing Prostate Cancer

Comparative analysis of diagnostic performance of P.I.R.A.D.S of bp/mp-MRI of prostate and Intraprostatic SUVmax of PSMA-PET, compared with ISUP Grading of Prostate Biopsy for diagnosing Prostate Cancer in a University Teaching Hospital in Karnataka. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/10/075192
Enrollment
128
Registered
2024-10-14
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N428- Other specified disorders of prostate

Interventions

Control Intervention1: Intraprostatic SUVmax of PSMA-PET: Intraprostatic SUVmax Value of greater than 9.5 is considered significant. Control Intervention2: ISUP grading of prostate biopsy: Gleason Sco

Sponsors

Dr Puppala Vinayaka Vishnu Vardhan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with suspicion of prostate cancer on digital rectal examination Elevated serum PSA level > 3 ng/dl.

Exclusion criteria

Exclusion criteria: Patients who have undergone Prostate biopsy, bp/mp-MRI and PSMA-PET elsewhere Coagulopathy Painful anorectal conditions Significant immunosuppression Acute prostatitis Contraindications for MRI Contraindications for PET scan

Design outcomes

Primary

MeasureTime frame
The Data will be analysed to determine if bp/mp-MRI and PSMA PET can predict avoiding a biopsy in patient with clinically significant prostate cancerTimepoint: 2 years—

Secondary

MeasureTime frame
1)Accuracy of ISUP Grading of prostatic biopsy alone in detetcting prostate cancer 2)Accuracy of PIRADS of bp/mp-MRI alone in detecting prostate cancer 3)Accuracy of intraprostatic SUVmax value of PSMA PET alone in detecting prostate cancer 4)Accuracy of PIRADS of bp/mp-MRI of prostate with intraprostatic SUVmax of PSMA PET in detecting prostate cancer.Timepoint: 2 years—

Countries

India

Contacts

Public ContactDr Puppala Vinayaka Vishnu Vardhan

Kasturba Hospital, Manipal

Padmaraj.hegde@manipal.edu9900264579

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026