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Effect of Serum Cortisol Levels on Reversal of Shock in Adults with Septic Shock.

Effect of Serum Cortisol Levels on Reversal of Shock in Adults with Septic Shock- A Prospective Observational Study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2024/10/075182
Enrollment
180
Registered
2024-10-14
Start date
Unknown
Completion date
Unknown
Last updated
2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: D899- Disorder involving the immune mechanism, unspecified

Interventions

Intervention1: NIL: NIL Control Intervention1: NIL: NIL

Sponsors

Dr DMThappaIntra Mural Research FundJIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Adults with septic shock requiring high vasopressor therapy to maintain MAP of = 65 mmHg for more than one hour, despite adequate fluid therapy.

Exclusion criteria

Exclusion criteria: 1.H/o Hypothalamic-pituitary-adrenal axis dysfunction 2.H/o Glucocorticoid/estrogen therapy 3. Patients with autoimmune disorders 4. Pregnancy 5. H/o drug intake that influence HPA axis response. (Eg: ketoconazole).

Design outcomes

Primary

MeasureTime frame
To compare the proportion of patients develops reversal of shock between responders and non-responders.Timepoint: Time to reversal of shock,28 day mortality benefit.—

Secondary

MeasureTime frame
To compare the 28 days mortality between critically ill septic shock adults between responders and non-responders. To compare the length of ICU stay between critically ill septic shock adults between responders and non-responders. To compare the need for RRT between critically ill septic shock adults be-tween responders and non-responders. Timepoint: 28 days of mechanical ventilator free days.—

Countries

India

Contacts

Public ContactDr Senthilnathan M

Autonomous institution

ujjaini.pandi@yahoo.com9500421367

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026