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A clinical trial to study the effects of intraarticular injections of Platelet Rich Plasma and Platelet Rich Fibrin in patients with early osteoarthritis of knee

A comparative study of clinico-functional outcomes of intraarticular Platelet Rich Plasma and Platelet Rich Fibrin in the management of early osteoarthritis of knee â?? prospective randomized control trial - nil

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/075179
Enrollment
126
Registered
2024-10-14
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M179- Osteoarthritis of knee, unspecified

Interventions

Intervention1: Plasma rich platelets: Concentrated platelets, derived from autologous blood, are concentrated into a polymer called platelet-rich plasma (PRP). PRP has chemotactic and mitogenic proper

Sponsors

Dr Ankit
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with early OA knee and Kellgren and Lawrence Scale (K&L) stage I and II. Patient with persistent symptoms (pain, joint stiffness etc) irrespective of being treated with conservative treatment, including physical therapy, manipulation. Patients were not under any other treatments for Osteoarthritis in the last month besides occasional analgesics.

Exclusion criteria

Exclusion criteria: Patients with severe osteoarthritis ( K& L stage III and IV) Patient treated with long release corticosteroids infiltration over the last month Patient on immune suppresor or chemotherapy treatment Local/ general infections; patient with previous joint replacement Actue rheumatoid arthritis and rheumatoid immune diseases Low platelets (100,000) or low fibrinogen

Design outcomes

Primary

MeasureTime frame
To compare the clinico-functional outcome of intraarticular platelet rich plasma and platelet rich fibrin in the management of early osteoarthritis of knee at 24th weekTimepoint: 24th week

Secondary

MeasureTime frame
To compare the clinico-functional outcome of intraarticular platelet rich plasma & platelet rich fibrin in the management of early osteoarthritis of knee at 2nd week, 4th week, 8th week, 12th week,24th weekTimepoint: 2nd week, 4th week, 8th week, 12th week, 24th week

Countries

India

Contacts

Public ContactDr Hariprasad S

Sri Devaraj Urs Academy of Higher Education and Research

DRHARIPRASAD.ORTHO@GMAIL.COM9686071188

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026