Variation in the induction dose and time of propofol on giving inhaled nitrous oxide during induction A prospective randomised controlled study

Variation in induction dose and time of propofol on administering inhaled nitrous oxide during induction A prospective randomized controlled study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075178

Enrollment

Registered

2024-10-14

Start date

Unknown

Completion date

Unknown

Last updated

2024-11-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: variation in induction dose and time of propofol on administering inhaled nitrous oxide during induction: •Patients will be divided into two groups randomly. Group A : Will receive a m

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients proposed for elective surgical procedures under general anaesthesia. 2.ASA 1 and 2

Exclusion criteria

Exclusion criteria: 1.Pregnant female. 2.Morbidly obese patients. 3.Patients with allergy to anesthetic agents. 4.Patients with difficult airway. 5.Patients with contraindications to the utilisation of N2O like increased intracranial pressure,obstruction of the bowel, pneumothorax, surgeries of the middle ear.

Design outcomes

Primary

Measure	Time frame
1) To evaluate the variation in induction dose of propofol on administering inhaled nitrous oxideTimepoint: The dose at which the patient achieves apnea - at 2min or 3 mins	—

Secondary

Measure	Time frame
2) To evaluate the variation in induction time of propofol on administering inhaled nitrous oxideTimepoint: the time at which the patient achieves apnea, The various hemodynamic parameters like HR,MAP,SBP,DBP will be recorded at specific intervals like Preoperatively - T1 ; Before the start of propofol infusion - T2 ; 1 minute after the start of infusion - T3 ; 2 minutes after the start of infusion - T4 ; 3 minutes after the start of infusion - T5 ; 4 minutes after the start of infusion - T6 ; apneic state - T7 ; Before intubation - T8 ; After intubation - T9.	—

Measure

Time frame

2) To evaluate the variation in induction time of propofol on administering inhaled nitrous oxideTimepoint: the time at which the patient achieves apnea, The various hemodynamic parameters like HR,MAP,SBP,DBP will be recorded at specific intervals like Preoperatively - T1 ; Before the start of propofol infusion - T2 ; 1 minute after the start of infusion - T3 ; 2 minutes after the start of infusion - T4 ; 3 minutes after the start of infusion - T5 ; 4 minutes after the start of infusion - T6 ; apneic state - T7 ; Before intubation - T8 ; After intubation - T9.

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Countries

India

Contacts

Public ContactSiri chandana

Sri devraj urs medical college

dr.nkiran@gmail.com9740468460

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026