Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: NIL: NIL
Sponsors
AIIMS Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: Patients Undergoing Elective Surgeries Patients adherent to routine fasting protocols before surgery.
Exclusion criteria
Exclusion criteria: 1. Patients with severe hypertension or SBP more than 160mmHg or hemodynamic instability. 2. Patients with baseline MAP less than 70mmHg or SBP less than 90mmHg. 3. Patients with history of Atherosclerosis, arrhythmia, symptomatic cardiac patients and major valvular heart disease. 4. Patients with Diabetes having autonomic neur. 5. Patients with severe pulmonary disease, or respiratory insufficiency or features of Cor Pulmonale. 6. Hypertensive patients on ACE inhibitors or Angiotensin receptor blockers before surgery. 7. Chronic Kidney Disease patients with AV fistula or on dialysis. 8. Patients on prolonged fasting. 9. Patients failing to comply with simulated end inspiraotry occlusion maneuver. 10. Patients in which getting clear and effective USG images and measurements are not possible. 11. Patients with recent history of cerebrovascular accidents or transient ischemic attacks. 12. Patients with significant carotid artery stenosis of more than 50 percent or other carotid abnormalities detected on preoperative imaging. 13. Patients with history of recent myocardial infarction or unstable angina. 14. Patients with a history of significant bleeding disorders or active bleeding at the time of surgery. 15. Patient with history of severe neurological disorders affecting autonomic function such as parkinsons disease or multiple system atrophy. 16. Patients with history of severe anaemia with hemoglobin less than 8, or requiring ongoing blood tranfusions. 17. Patients with history of severe liver disease or dysfunction. 18. Patients with history of recent major surgery or trauma within the last month. 19. Patients with history of severe cognitive impair psychiatric disorders that may affect their ability to participate in the study. 20. Patients with history of significant vasculitis or vascular abnormalities affecting carotid arteries. 21. Patients with history of recent respiratory tract infections or pneumonia within the last two weeks. 22. Patients with known pregnancy or breastfeeding at the time of study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Baseline Carotid Flow Time, Baseline Corrected Carotid Flow time, Carotid flow time and corrected carotid flow time following end inspiratory occlusion maneuver, change in corrected carotid flow time following end inspiratory occlusion maneuver. NIBP measurements of SBP, DBP and MAP at different time points after endotracheal intubation.Timepoint: T0 - Baseline Ts - Following End inspiratory occlusion maneuver T1 - 3 minutes after endotracheal Intubation T2 - 5 minutes after endotracheal intubation T3 - 7 minutes after endotracheal intubation T4 - 9 minutes after endotracheal intubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| Carotid Peak systolic velocity- Baseline and Following End inspiratory occlusion maneuver, change in carotid peak systolic velocity following end inspiratory occlusion maneuver.Timepoint: T0 - Baseline Ts - Following End inspiratory occlusion maneuver T1 - 3 minutes after endotracheal Intubation T2 - 5 minutes after endotracheal intubation T3 - 7 minutes after endotracheal intubation T4 - 9 minutes after endotracheal intubation.;Hemodynamic parameters such as Heart Rate , SBP, DBP, MAP and SPO2 baseline and following end inspiratory occlusion maneuver, change in hemodynamic parameters following end inspiratory occlusion maneuver.Timepoint: T0 - Baseline Ts - Following End inspiratory occlusion maneuver T1 - 3 minutes after endotracheal Intubation T2 - 5 minutes after endotracheal intubation T3 - 7 minutes after endotracheal intubation T4 - 9 minutes after endotracheal intubation. | — |
Countries
India
Contacts
Public ContactDr Kunal Biswakarma
All India Institute of Medical Sciences Rishikesh
Outcome results
None listed