Health Condition 1: I489- Unspecified atrial fibrillation and atrial flutter
Conditions
Interventions
Intervention1: Calcium channel blocker(Diltiazem): Diltiazem is given at 0.25mg/kg(max-20mg) intravenously followed by 0.35 mg/kg(max-30mg) after 15 mins to see response in heart rate
Control Interven
Sponsors
Department of Emergency MedicineAIIMS New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: All hemodynamically stable patients presenting to ED with ECG showing Atrial fibrillation with fast ventricular rate more than 110 beats per minute,consenting for study
Exclusion criteria
Exclusion criteria: 1.pregnancy 2.systolic blood pressure less than 90mm of mercury 3.heart rate more than 220 beats per minute 4.QRS duration more than 120 milliseconds 5.Febrile patients with temperature more than 38 celsius 6.ECG suggestive of acute ST elevation Myocardial infarction 7.History of allergy to Diltiazem or Metoprolol 8.Acute decompensated heart failure patients with ejection fraction less than 40% or NYHA class 3,4 or patients with active wheezing or history of Bronchial asthma and Chronic obstructive pulmonary disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the effects of Metoprolol versus Diltiazem in decreasing heart rate to less than 110 beats per minute or 20% reduction of initial heart rate within 30 minutes of drug intakeTimepoint: The outcome of drug intake are estimated after 30 minutes. | — |
Secondary
| Measure | Time frame |
|---|---|
| To evaluate the incidence of hypotension(systolic blood pressure to less than 90 mm of mercury) and bradycardia (heart rate less than 60 beats per minute)Timepoint: within 30 minutes of drug administration;To evaluate the incidence of length of ED stayTimepoint: Within 30 minutes of drug administration;To evaluate the incidence of requirement of second dose of same medication or subsequent doses of other class medication for rate controlTimepoint: Within 30 minutes of drug administration | — |
Countries
India
Contacts
Public ContactDr Anil Akhil
AIIMS New Delhi
Outcome results
None listed