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We compared how well brain stimulation helps OCD patients when targeting two different brain areas supplementary motor area and left dorsolateral prefronatal cortex

A naturalistic, quasi- experimental study comparing the effectiveness of accelerated TBS targeting left SMA and left DLPFC among patients with obsessive compulsive disorder - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/075148
Enrollment
46
Registered
2024-10-11
Start date
Unknown
Completion date
Unknown
Last updated
2026-08-03

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F42- Obsessive-compulsive disorder

Interventions

Intervention1: Repeatitive trans cranial magnetic stimulation in ocd opatients: to study the efficacy of rTMS in OCD patients targeting different areas Protocol 1 at left DLPFC
aiTBS with an amplitude of 100%, frequency, 20 trains, pulses in a train 300, and total pulses 600 will be delivered in a single session. Protocol 2 at left SMA: acTBS with an amplitude of 100%, a fre

Sponsors

King Georges Medical University
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients with a diagnosis of OCD as per DSM 5 criteria 2 Age between 18 and 60 years 3 OCD with severity moderate or higher YBOCS MORE THAN 15 4 Patient on a stable dose of SSRI medication Fluoxetine equivalent dose of 40 to 80 mg per day for at least 1 month and a maximum duration of 3 months 5 Participant agreeing to give written informed consent

Exclusion criteria

Exclusion criteria: 1 Other comorbid psychiatric illnesses (except tobacco use disorder and mild to moderate depression) 2 Any medical morbidity that significantly interferes with psychiatric assessmenent.

Design outcomes

Primary

MeasureTime frame
To compare the effectiveness of acTBS protocol targeting left supplementary motor area and aiTBS at left dorsolateral prefrontal cortex in reducing the YBOCS score among patients with Obsessive Compulsive DisorderTimepoint: Assessment will be done at baseline, week 1, week 2, and week 4 of the study.—

Secondary

MeasureTime frame
Secondary objective To determine the change in resting motor threshold (RMT) among patients with Obsessive Compulsive Disorder with acTBS protocol targeting left supplementary motor area versus aiTBS at left dorsolateral prefrontal cortex To determine the change in depressive symptoms and subjective well-being among patients with Obsessive Compulsive Disorder with acTBS protocol targeting left supplementary motor area versus aiTBS at left dorsolateral prefrontal cortexTimepoint: baseline, after 10 sessions, after 20 sessions, and 4 weeks after 20 sessions—

Countries

India

Contacts

Public ContactPriyanshi chaudhary

King Georges Medical University

Drsujita@gmail.com9956273747

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Aug 9, 2026