Health Condition 1: R768- Other specified abnormal immunological findings in serum
Conditions
Interventions
Intervention1: Colostrum: Oropharyngeal administration of mother’s colostrum in preterm neonates
Intervention2: Mother’s colostrum: Oropharyngeal administration of mother’s colostrum, 0.2 ml, 4 hourly
Sponsors
Intramural Research Grant, University College of Medical Sciences
Eligibility
Inclusion criteria
Inclusion criteria: Preterm neonates with 30-34 weeks of gestational age, admitted in the NICU
Exclusion criteria
Exclusion criteria: 1. Neonates on enteral feeding 2. Neonates who received blood transfusions during the study period 3. Major congenital anomalies 4. Neonates born to HIV positive or Hepatitis B positive or Hepatitis C positive mothers 5. Neonates born to mothers who are on any antipsychotics or chemotherapeutic agents
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The mean concentrations of serum IgA in both groups (the colostrum group and the control group)Timepoint: On day 1 and day 5 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. The mean concentrations of serum immunoglobulins (IgG and IgM) and serum inflammatory markers (IL-6 and TNF alpha) in both groups. 2. The proportion of feed intolerance and necrotizing enterocolitis in both groups.Timepoint: On day 1 and day 5 | — |
Countries
India
Contacts
Public ContactDr Megha Kumari
University College of Medical Sciences and GTB Hospital
Outcome results
None listed