A study to compare Aortocaval index and IVC collapsibility index for fluid administration in septic shock patients

To compare Aorto-Caval Index versus IVC Collapsibility Index in assessing fluid responsiveness in patients presenting with Septic Shock to Emergency Department – A Pilot Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/075067

Enrollment

100

Registered

2024-10-10

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R652- Severe sepsis

Interventions

Intervention1: Aorto-caval index: Aorto-Caval index is taken as the ratio of maximum diameter of IVC to the maximum diameter of Aorta. Control Intervention1: IVC Collapsibility Index: IVC Collapsibil

Eligibility

Inclusion criteria

Inclusion criteria: All patients presenting to the Emergency Department in Septic Shock (Systolic BP less than 90mmHg or Shock Index more than 1) as screened using NEWS score more than or equal to 5. Age greater than or equal to 18 years Valid consent given by the patient or Legally Accepted Representative (LAR)

Exclusion criteria

Exclusion criteria: Patients less than 18 years of age Patients presenting in Cardiac Arrest. Patients with ascites, increased intra-abdominal pressure or intra-abdominal pathologies like space occupying lesions. Pregnant women Intubated patients on mechanical ventilation support.

Design outcomes

Primary

Measure	Time frame
To compare Aorto-Caval Index versus IVC Collapsibility Index in assessing fluid responsiveness in patients presenting with Septic Shock to Emergency Department.Timepoint: at baseline, 30 minutes	—

Secondary

Measure	Time frame
To assess the effect of Passive Leg Raising (PLR) on Aorto-caval index & Inferior Vena Cava (IVC) Collapsibility Index.Timepoint: at baseline, 30 minutes;To check the feasibility of incorporating Aorto-Caval Index in RUSH protocol for baseline fluid status & dynamic fluid resuscitation.Timepoint: at baseline, 30 minutes;To compare the difference between Aorto-caval index obtained from subxiphoid & transhepatic right coronal views.Timepoint: at baseline, 30 minutes	—

Measure

Time frame

To assess the effect of Passive Leg Raising (PLR) on Aorto-caval index & Inferior Vena Cava (IVC) Collapsibility Index.Timepoint: at baseline, 30 minutes;To check the feasibility of incorporating Aorto-Caval Index in RUSH protocol for baseline fluid status & dynamic fluid resuscitation.Timepoint: at baseline, 30 minutes;To compare the difference between Aorto-caval index obtained from subxiphoid & transhepatic right coronal views.Timepoint: at baseline, 30 minutes

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Countries

India

Contacts

Public ContactDr Harikrishnan S

All India Institute of Medical Sciences, New Delhi

ranjan.prakashmishra@gmail.com8826118924

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026