A Study to compare two painkillers in Surgery

A Prospective Randomised Comparative Study Efficacy of IV Paracetamol versus IV Ibuprofen Infusion used as Pre-Emptive Analgesia In Patient Undergoing Elective Laparoscopic Cholecystectomy under General Anaesthesia - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/074976

Enrollment

Registered

2024-10-09

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: laparoscopic cholecystectomy: Premptive analgesic agent in laparoscopic cholecystectomy under general anesthesia with duration of 60 to 90 minutes. Control Intervention1: nil: nil Contr

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA grade I and grade II Patients 2.Patients undergoing elective laparoscopic cholecystectomy under GA 3.Patients with informed consent

Exclusion criteria

Exclusion criteria: 1. Patient or Parent’s refusal, 2. Pregnancy, patients with asthma or chronic lung disease, patients with heart diseases, patients with renal failure and dialysis 3. Known allergy or hypersensitivity to Ibuprofen & paracetamol (NSAIDS) 4. Coagulopathy, a history of gastrointestinal bleeding, high blood pressure, a history of anemia, consumption of warfarin 5. 1st 2nd and 3rd degree heart block

Design outcomes

Primary

Measure	Time frame
Post-Operative Analgesia- Timing of requiring first dose of Rescue Analgesic (IV Tramadol) Timepoint: Outcomes will be assessed at- 15min 30min 1 hr 2 hr 4 hr 6 hr 8 hr 10 hr 12 hr	—

Secondary

Measure	Time frame
Secondary outcomes are to study- 1.Intra operative hemodynamic changes 2.Post op opiod requirements 3.Side effects if any Timepoint: Secondary outcomes will be assessed at- Baseline (30 Min Prior To Anaesthesia) Before Induction Just After Intubation 15 Min After Intubation 30 Min After Intubation 45 Min After Intubation 60 Min After Intubation Just after extubation	—

Countries

India

Contacts

Public ContactDr Abhishek Goel

LLRM Medical College Meerut

dr_abhishek1979@rediffmail.com9927951681

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026