To evaluate the efficacy of Dexmedetomidine versus Lignocaine on quality of extubation in patients undergoing lumbar spine surgery under general anesthesia.

Effect of Dexmedetomidine versus Lignocaine on quality of extubation in patients undergoing lumbar spine surgery under general anesthesia: a parallel group, double blind, randomized study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/074944

Enrollment

Registered

2024-10-08

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M483- Traumatic spondylopathy

Interventions

Intervention1: Dexmedetomidine: Effect of intravenous Dexmedetomidine 0.5mcg/kg on hemodynamic stability and cough response during extubation Control Intervention1: Lignocaine: Intravenous Lignocaine

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anesthesiologists physical status (ASA) I & II Scheduled for elective lumbar spine surgery under general anesthesia with endotracheal intubation

Exclusion criteria

Exclusion criteria: Previous history of CAD, bradycardia, need for vasopressor support. Ischemic, congestive cardiac disease, renal, hepatic and respiratory dysfunction. Patients on betablockers, clonidine, calcium channel blockers like diltiazem, verapamil, anticonvulsants. Non-consenting patients Drug hypersensitivity to dexmedetomidine and lidocaine. If the patient had received lidocaine or dexmedetomidine within 2 hours of the intended time of administration. Patient needing postoperative elective mechanical ventilation.

Design outcomes

Primary

Measure	Time frame
Quality of extubation assessed by Cough grading Timepoint: Quality of extubation assessed by Cough grading after 5mins of ectubation	—

Secondary

Measure	Time frame
Incidence of pressor response at extubation. Agitation/sedation at extubation assessed by Ramsay scale Time to emergence and time to extubation Patient comfort on a Likert scaleTimepoint: After 5,10,30 mins of extubation	—

Countries

India

Contacts

Public ContactDr Sunaina Tejpal Karna

AIIMS, BHOPAL

drtejpal@gmail.com09540946869

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026