Health Condition 1: J80- Acute respiratory distress syndrome Health Condition 2: J471- Bronchiectasis with (acute) exacerbation Health Condition 3: J09-J18- Influenza and pneumonia Health Condition 4: J60-J70- Lung diseases due to external agents Health Condition 5: J454- Moderate persistent asthma Health Condition 6: J90-J94- Other diseases of the pleura Health Condition 7: J80-J84- Other respiratory diseases principally affecting the interstitium Health Condition 8: J18- Pneumonia, unspecified
Conditions
Interventions
Intervention1: Application of high flow nasal cannula in patients with hypoxemic respiratory failure.: Patient with hypoxemic respiratory failure arriving at department(RICU) will be assessed at 0 hrs
respiratory rate 40/min or Spo2 90 despite max FiO2, worsening hypercapnia, deterioration of GCS 12, severe hemodynamic instability.
After HFNC application, Respiratory rate oxygenation index(ROX) AN
Sponsors
VMMC and SAFDARJUNG HOSPITAL
Eligibility
Inclusion criteria
Inclusion criteria: Patient presenting with acute hypoxemic respiratory failure (room air spo2 equal to less than 90% or PaO2 less than 60 mmhg). The need for oxygen supplemental via face mask greater than 9 L/min to maintain spo2 greater than 92%.
Exclusion criteria
Exclusion criteria: Requiring immediate mechanical ventilation Cardiopulmonary arrest Pneumothorax Severe respiratory acidosis or suspected hypercapnic respiratory failure. Hemodynamic instability with MAP less than 65mmhg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary outcome was defined as no intolerance requiring hfnc removal and no escalation to invasive or non invasive ventilation within 48 hours after hfnc application i.e HFNC will be terminated if any of the following criteria for termination is met adopted from British thoracic guidelines; respiratory rate 40/min or Spo2 90 despite max FiO2, worsening hypercapnia, deterioration of GCS 12, severe hemodynamic instability.Timepoint: After applying HFNC, respiratory rate oxygenation (ROX) and HACOR(The HACOR score is based on five components: heart rate, acidosis, consciousness, oxygenation, and respiratory rate) score will be calculated at 1,2 and 6 hours after first application of HFNC. Patient will be observed for 48 hours to see if there is escalation of oxygenation support in the form of ventilator(invasive or non invasive) | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare individual components of the scoring indexTimepoint: Individual components of scoring (heart rate, respiratory rate & SpO2) will be assessed at 1,2 & 6 hours after application of HFNC. | — |
Countries
India
Contacts
Public ContactTejawat Kushal Kumar
Vardhaman mahavir medical College and Safdarjung hospital
Outcome results
None listed