Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Surgical excision arm: This will be a split face study in which Xanthlasma palpebrum (XP) lesions involving the upper and/or lower eyelids of one eye of each patient will be randomized
Sponsors
JIPMER Pondicherry
Eligibility
Inclusion criteria
Inclusion criteria: ) Age 18 years or above 2) Patients with bilateral XP (involving at least one eyelid of both eyes) 3) XP involving one third or lesser of palpebral area in all the involved eyelids
Exclusion criteria
Exclusion criteria: 1) Patients with XP lesions with vertical height greater then one third of height of palpebral area (eyelids) will be excluded 2) Patients with XP lesions encroaching within 2 mm of medial or lateral canthus will be excluded 3) Patient with history of hypertrophic scars, keloids 4) Patients with coagulation disorders 5) Pregnancy and lactation Patients with extensive XP involving more than one third of palpebral area or vertical height greater then one third of height of palpebral area (eyelids) in any of the eyelids of any of the eye will be excluded owing to relative inefficacy of TCA in treating large XP lesions and also due to poten-tial difficulty in primary closure while doing surgical exci-sion of large lesions. Patients with XP lesions encroaching within 2 mm of medial or lateral canthus will be excluded to ensure safety of eyes during the procedures.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1) Number of XPU achieving complete clinical response (100 % reduction in size) in group A versus group B.Timepoint: week 12 | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes 1) Percentage reduction in size of XPU. 2) Number of XPU achieving excellent , very good, good, moderate and poor clinical response. 3) Number of XPU achieving excellent, good and accepta-ble cosmetic improvement. 4) PGA for XPU in both groups 5) Adverse effects in both the groups XPU. 5) Number of days of post- operative pain in XPU. Timepoint: week 12 | — |
Countries
India
Contacts
Public ContactSheetanshu Kumar
Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER) Puducherry
Outcome results
None listed