Health Condition 1: J308- Other allergic rhinitis
Conditions
Interventions
Intervention1: Oral antibiotics and oral steroids: Oral antibiotics (amoxicillin and clavulanic acid 625 mg TDS for adults and children weighing more than 40 kg
if intolerance to Amoxycillin present then 3 rd generation cephalosporins will be administered) with steroids in tapering dose (1 mg/kg OD) in tapering doses for 15 days
Control Intervention1: Oral It
Sponsors
Government Medical College and Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients of allergic fungal rhinosinusitis diagnosed on the basis of NCCT scan Nose Paranasal sinuses findings.
Exclusion criteria
Exclusion criteria: 1.History of previous surgery 2. Contraindications of steroid use: a. Diabetes mellitus b. Peptic ulcer disease c. Tuberculosis d. Osteoporosis e. Glaucoma f. Congestive heart failure g. Subcapsular cataract 3. Samter’s triad (bronchial asthma, nasal polyps, aspirin intolerance) 4. Hepatic disease 5. Drugs metabolised extensively by CYP3A4
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare efficacy of oral itraconazole and oral antibiotics versus oral steroids in Allergic Fungal Rhinosinusitis using: 1. NCCT nose PNS (Lund and Mackey radiological scoring system) 2. serum Total IgE levels Timepoint: 15 days per participant | — |
Secondary
| Measure | Time frame |
|---|---|
| Compare efficacy of oral itraconazole and oral antibiotics versus oral steroids in Allergic Fungal Rhinosinusitis using: 1. nasal endoscopy (Kupferberg Endoscopic Scoring and Lund Kennedy scoring system) 2. Sinonasal Outcome Test -22 score and Visual analogue scale scores with respect to nasal endoscopic scoringTimepoint: 15 days per participant | — |
Countries
India
Contacts
Public ContactTanisha Goel
Government Medical College and Hospital, Chandigarh
Outcome results
None listed