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comparing usefulness of lignocaine and magnesium sulphate in reducing succinylcholine produced muscle twitching and postoperative body pain

A comparative study of effect of intravenous magnesium sulphate versus lignocaine in reduction of succinylcholine induced fasciculations and postoperative myalgia in patients undergoing elective surgery - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/074913
Enrollment
94
Registered
2024-10-08
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium sulphate: 30mg/kg of Magnesium Sulphate in 10 ml isotonic 0.9% saline slowly over ten minutes intravenously under monitoring before the induction anesthesia. Control Interve

Sponsors

Dr NIDHISHREE V
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status grade I and II 2.Modified Mallampati Airway (MMA) (Samsoon Young) class I And II 3. Scheduled for elective surgeries under general anesthesia. 4. Patient who are willing to give consent.

Exclusion criteria

Exclusion criteria: 1. Patients with history of significant systemic disorders (cardiovascular, respiratory, central nervous system or renal system) 2. Pre-existing musculoskeletal disorders. 3. Hypermagnesemia with a diagnosed condition or with altered serum values, altered liver function tests. 4.Beta-adrenergic or calcium channel blocker usage 5. Known hypersensitivity and contraindications to study drugs in allergic history family history.

Design outcomes

Primary

MeasureTime frame
To valuate the occurrence of succinylcholine induced fasciculation and post operative myalgia after pre-treatment with IV Mgso4 30mg/kg and IV preservatives free 2% lignocaine 1.5mg/kgTimepoint: From General anaesthesia induction to 24 hour postoperative period—

Secondary

MeasureTime frame
1. To compare the severity of succinylcholine induced fasciculation and postoperative myalgia. 2. To compare the requirement of analgesics for postoperative myalgia for other than the surgical site pain using Menckes Standardised QuestionnaireTimepoint: From General anaesthesia induction to 24 hour postoperative period—

Countries

India

Contacts

Public ContactDr NIDHISHREE V

ESIC Medical College PGIMSR

gbsumaravi@gmail.com9538301444

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026