Comparative study of intravenous bolus of dexmeditomidine or magnesium sulphate on vital response to carboperitonium.

Comparative study of intravenous bolus of the dexmeditomidine or magnesium sulphate on haemodynamic response to carboperitonium -A prospective randomized double blind study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/074868

Enrollment

Registered

2024-10-07

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K800- Calculus of gallbladder with acutecholecystitis

Interventions

Intervention1: inj Magnesium sulphate: 30 MG IV stat 10 minutes Control Intervention1: dexmedetomidine: 1 mcg stat iv 10 minutes

Eligibility

Inclusion criteria

Inclusion criteria: • 1. American Society of Anaesthesiologists physical status I,II[19](ANNEXURE III). 2. Patients with age :20 to 60 Years of both sexes. 3. BMI (body mass index) = 30 kg/m2 4. Patients undergoing elective laparoscopic cholecystectomy

Exclusion criteria

Exclusion criteria: 1. American Society of Anaesthesiologists physical status I,II[19](ANNEXURE III). 2. Patients with age :20 to 60 Years of both sexes. 3. BMI (body mass index) = 30 kg/m2 4. Patients undergoing elective laparoscopic cholecystectomy

Design outcomes

Primary

Measure	Time frame
To study the cardiovascular response (change in MAP) at different time intervals following the creation of pneumoperitoneum in patients receiving either I.V dexmedetomidine or magnesium sulphate boluses. To study the cardiovascular response (change in MAP) at different time intervals following the creation of pneumoperitoneum in patients receiving either I.V dexmedetomidine or magnesium sulphate boluses. TO ALL CAUSE MORBIDITYTimepoint: 6 HRS	—

Measure

Time frame

To study the cardiovascular response (change in MAP) at different time intervals following the creation of pneumoperitoneum in patients receiving either I.V dexmedetomidine or magnesium sulphate boluses. To study the cardiovascular response (change in MAP) at different time intervals following the creation of pneumoperitoneum in patients receiving either I.V dexmedetomidine or magnesium sulphate boluses. TO ALL CAUSE MORBIDITYTimepoint: 6 HRS

—

Secondary

Measure	Time frame
1. To study the changes in heart rate (HR), systolic blood pressure (SBP) & diastolic blood pressure (DBP) at specified time intervals following creation of pneumoperitoneum 2. To asses postoperative sedation using Ramsay sedation score (RSS)[16] at specified time interval post extubation(16). No.of patients reaching RSS of 2 score is taken.[Annexure 1] 3. To compare the time for first request of analgesia postoperatively – defined as whenever the patient complains of pain or when numerical rating scale[17] (NRS) 4[Annexure II ] 4. Number of propofol boluses required perioperatively by the two groups will be compared. 5. Number of boluses of atropine, ephedrine & phenylephrine required intraoperatively by the two groups will also be compared. Timepoint: 15 MINUTES AND 6HRS	—

Measure

Time frame

1. To study the changes in heart rate (HR), systolic blood pressure (SBP) & diastolic blood pressure (DBP) at specified time intervals following creation of pneumoperitoneum 2. To asses postoperative sedation using Ramsay sedation score (RSS)[16] at specified time interval post extubation(16). No.of patients reaching RSS of 2 score is taken.[Annexure 1] 3. To compare the time for first request of analgesia postoperatively – defined as whenever the patient complains of pain or when numerical rating scale[17] (NRS) 4[Annexure II ] 4. Number of propofol boluses required perioperatively by the two groups will be compared. 5. Number of boluses of atropine, ephedrine & phenylephrine required intraoperatively by the two groups will also be compared. Timepoint: 15 MINUTES AND 6HRS

—

Countries

India

Contacts

Public ContactDr A RAMESH

Sri venkateswara institute of Medical Scince(SVIMS)

hemanthn1973@gmail.com9440285634

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026