Study on Effective Treatments for Dentinal Hypersensitivity: GLUMA, CPP-ACP with Chitosan Nanoparticles, and Diode Laser - A Single Blinded Randomized Control Trial

EVALUATION OF GLUMA, CPP-ACP WITH CHITOSAN NANOPARTICLES AND DIODE LASER IN REDUCING DENTINAL HYPERSENSITIVITY - A SINGLE BLINDED RANDOMIZED CONTROL TRIAL - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/074822

Enrollment

Registered

2024-10-07

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K031- Abrasion of teeth

Interventions

Intervention1: CPP-ACP WITH CHITOSAN NANOPARTICLES: CPP-ACP MIXED WITH CHITOSAN NANOPARTICLES IN THE RATIO OF 1:1 Control Intervention1: GLUMA: AQUEOUS SOLUTION OF 5% GLUTARALDEHYDE AND 35 % HEMA Cont

Eligibility

Inclusion criteria

Inclusion criteria: The study includes subjects of 35-55 years of age. Dentinal hypersensitivity caused by gingival recession and non-carious cervical defects are included in the study The sensitivity scores measured 2 or more in the VAS are eligible to be included under the study Less than 1mm dentinal defect so that restoration need not be done. Minimum of 2 teeth and three quadrants which meets the desired criteria are taken.

Exclusion criteria

Exclusion criteria: Subjects who had undergone periodontal surgery within 3 months or with orthodontic appliances or bridges Pregnant or lactating mothers are excluded from study. Teeth with caries, cracks or fractures in the cervical area Usage of toothpastes containing desensitizing agents in the last 3 months Subjects with systemic diseases such as eating disorders, chronic diseases, use of pacemakers, major psychiatric disorders, heavy smoking or alcohol abuse, MI history in past 6 months Subjects with severe oral pathologies and diseases

Design outcomes

Primary

Measure	Time frame
Comparison of clinical effectiveness of GLUMA, CPP-ACP with chitosan nanoparticles and diode laser in reducing the dentinal hypersensitivity.Timepoint: The evaluation of the efficacy of the three agents were tested at baseline,1,7,14 and 21 days	—

Secondary

Measure	Time frame
•To assess the pre-treatment & post-treatment sensitivity scores using visual analog scale, air blast, cold graded thermal test & mechanical method in GLUMA. •To assess the pre-treatment & post-treatment sensitivity scores using visual analog scale, air blast, cold graded thermal test & mechanical method in CPP-ACP mixed chitosan nanoparticles. •To assess the pre-treatment & post-treatment sensitivity scores using visual analog scale, air blast, cold graded thermal test & mechanical method in diode laser. Timepoint: The test is done at baseline ,1,7 14 & 21 days	—

Measure

Time frame

•To assess the pre-treatment & post-treatment sensitivity scores using visual analog scale, air blast, cold graded thermal test & mechanical method in GLUMA. •To assess the pre-treatment & post-treatment sensitivity scores using visual analog scale, air blast, cold graded thermal test & mechanical method in CPP-ACP mixed chitosan nanoparticles. •To assess the pre-treatment & post-treatment sensitivity scores using visual analog scale, air blast, cold graded thermal test & mechanical method in diode laser. Timepoint: The test is done at baseline ,1,7 14 & 21 days

—

Countries

India

Contacts

Public ContactDr Krishnaprasad L

KVG Dental College and Hospital Sullia

drkpdental@yahoo.co.in9448012084

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026