To Study the Effect of Local Insulin Injection in Patients with Diabetic Foot Ulcer.

Effect of Local Insulin Injection on Wound Healing in Patients with Diabetic Foot Ulcer. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/074708

Enrollment

Registered

2024-10-04

Start date

Unknown

Completion date

Unknown

Last updated

2026-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E115- Type 2 diabetes mellitus with circulatory complications Health Condition 2: E114- Type 2 diabetes mellitus with neurological complications

Interventions

Intervention1: Insulin + Regular Dressing: Wound of the patient will be cleaned with sterile normal saline (0.9% NaCl)then wound will be injected with human soluble insulin (regular)diluted in 1 ml

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients who were diagnosed with diabetic foot ulcer. 2. Patients who are already on injectable insulin therapy subcutaneously with OHAs 3.voluntary participants with more than 18years who were able and willing to participate in the study 4.patients with relatively stable blood glucose levels, without the influence of diet, exercise, infection, stress or other factors that could affect systemic blood glucose 5.wounds without significant growth of granulation tissue. 6. Grade 2 and grade 3 ulcer according to European pressure ulcer classification.

Exclusion criteria

Exclusion criteria: 1. Patients with osteomyelitis, immunodeficient , varicose ulcer , patients with liver disease, kidney disease, skin malignancy and patients on chemotherapy or radiotherapy. 2. Patients with Hepatitis B , HCV or HIV positive.

Design outcomes

Primary

Measure	Time frame
-Surface Area of the wound that is increasing or decreasing. -Amount of Exudate from Wound and the type of Exudate whether it is foul smelling pus or serous fluid or serosanguinous discharge or Haemorrhagic. -Granulation tissue whether it is healthy red , Pale Yellow ,White or Necrotic. -Time duration required in healing of wound. Timepoint: â?¢Assessment of exudate, appearance of granulation, disappearance of slough , reduction in wound size will be seen on day 1,day 4 day 7 , day 14 and 21 between groups receiving insulin and saline dressing.	—

Measure

Time frame

-Surface Area of the wound that is increasing or decreasing. -Amount of Exudate from Wound and the type of Exudate whether it is foul smelling pus or serous fluid or serosanguinous discharge or Haemorrhagic. -Granulation tissue whether it is healthy red , Pale Yellow ,White or Necrotic. -Time duration required in healing of wound. Timepoint: â?¢Assessment of exudate, appearance of granulation, disappearance of slough , reduction in wound size will be seen on day 1,day 4 day 7 , day 14 and 21 between groups receiving insulin and saline dressing.

—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Anupriya

Adesh Institute of Medical Sciences and Rsearch

neeleshbansal2010@gmail.com9814975726

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Mar 14, 2026