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To compare the efficacy of pretreatment with lignocaine, dexmeditomidine or ketamine in providing relief from Propofol injection pain and withdrawal movements during induction of anaesthesia

Comparative study of pretreatment with Lignocaine, Dexmeditomidine or Ketamine in providing relief from Propofol injection pain and withdrawal movements during induction of anaesthesia - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/074696
Enrollment
96
Registered
2024-10-03
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Lignocaine: 2ml(40mg) of 2 % Lignocaine (preservative free) diluted unto 5ml using normal saline, intravenous, 1 minute before Propofol injection Intervention2: Dexmeditomidine: 0.5 mi

Sponsors

Shivangi Sharma
Lead Sponsor
Shri Bhauseheb Hire government medical college
Collaborator

Eligibility

Inclusion criteria

Inclusion criteria: 1. All patients from 18-65 years undergoing elective surgical procedures under general anaesthesia using endotracheal intubation 2.American Society of Anaesthesiologist grade I and II 3. Body mass index less than 30kg/metre square

Exclusion criteria

Exclusion criteria: 1. History of pulmonary, renal, hepatic, endocrine, neurological disease 2. Patients with cardiovascular diseases including hypertension on beta blockers, digitalis etc 3. Pregnant and lactating females 4. Patients on any sedatives or analgesics 5. Emergency surgical procedures 6.History of drug abuse or psychiatric illness 7. Hypersensitivity to study drugs 8. Subjects with anticipated difficulty in venous access

Design outcomes

Primary

MeasureTime frame
Degree of pain alleviation and withdrawal movements due to propofol injection during induction of anaesthesiaTimepoint: 6 months—

Secondary

MeasureTime frame
Hemodynamic parametersTimepoint: 6 months—

Countries

India

Contacts

Public ContactSandip Thorat

Shri Bhausaheb Hire government medical college

drsandipthorat@gmail.com9822542870

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026