Comparing Magnesium Sulphate and Dexmedetomidine for Attenuating Pressor Responses During Pneumoperitoneum in Laparoscopic Surgery: A Randomized Controlled Trial

Attenuation of pressor response to pneumoperitoneum in laparoscopic surgeries, comparison between magnesium sulphate and dexmedetomidine.A randomized control study. - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/074669

Enrollment

Registered

2024-10-03

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Magnesium sulfate vs. dexmedetomidine for Pressor response in laparoscopic surgery: Group A: Infusion of 50mg/kg of MgSo4 in 100 ml Normal Saline over 20 minutes prior to induction of A

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients undergoing laparoscopic surgeries under general anaesthesia. 2 ASA 1 and 2

Exclusion criteria

Exclusion criteria: 1 Patients with abnormal ECG, difficult airway 2 Patients with pre existing disease effecting NMJ 3 Patients with pre existing cardiac, renal, hepatic, cerebral diseases 4 Patients with seizure disorder, electrolyte abnormality 5 Patients with psychiatric disorders

Design outcomes

Primary

Measure	Time frame
Stastical analysis of the data will be performed using SPSS 20.0, descriptive statistics of SBP,DBP, MBP,and HR will be expressed using mean ± SD. Catagorical variables will be expressed as frequency and percentage. Pre and Post comparison within group will be done using Paired T test. Between the group comparison in all the parameters will be done using unpaired t test . A value 0.05 will be considered statistically significant.Timepoint: systolic blood pressure, diastolic blood pressure, mean blood pressure and heart rate are be documented at baseline, 1st min, 5th min, 10th min, 30th mins, 60th min, and at the end of surgery	—

Measure

Time frame

Stastical analysis of the data will be performed using SPSS 20.0, descriptive statistics of SBP,DBP, MBP,and HR will be expressed using mean ± SD. Catagorical variables will be expressed as frequency and percentage. Pre and Post comparison within group will be done using Paired T test. Between the group comparison in all the parameters will be done using unpaired t test . A value 0.05 will be considered statistically significant.Timepoint: systolic blood pressure, diastolic blood pressure, mean blood pressure and heart rate are be documented at baseline, 1st min, 5th min, 10th min, 30th mins, 60th min, and at the end of surgery

—

Secondary

Measure	Time frame
To compare which drug is better suitable for laparoscopic surgeries.Timepoint: by measuring hemodynamic parameters at time intervals at baseline,1st min,5th min, 10th min, 30 mins, 60 mins	—

Countries

India

Contacts

Public ContactRatan A Nalatwadmath

Shri devaraj urs medical college

Dr.nkiran@gmail.com9740468460

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026