Comparing Two Fluid Management Strategies in Critically Ill Children on Ventilators whether Less Fluid Improve Survival or not.

Restricted versus liberal maintenance fluid Strategy in mechanically ventilated children: A open-label Randomized control trial - NIL

Status

Recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/074654

Enrollment

Registered

2024-10-03

Start date

Unknown

Completion date

Unknown

Last updated

2025-05-26

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: B96- Other bacterial agents as the cause of diseases classified elsewhere Health Condition 2: J09-J18- Influenza and pneumonia Health Condition 3: R00-R09- Symptoms and signs involving the circulatory and respiratory systems Health Condition 4: G35-G37- Demyelinating diseases of the central nervous system Health Condition 5: K00-K95- Diseases of the digestive system

Interventions

Intervention1: Maintenance fluids (including regular drugs and infusions) will be 50% of estimated using Holliday segar formula: One group will be restricted maintenance fluid fifty percent.Maintenanc

Eligibility

Inclusion criteria

Inclusion criteria: Children aged 1-month to 15-years who are mechanically ventilated for at least 48 hours and hemodynamically stable

Exclusion criteria

Exclusion criteria: Cardiac disease, kidney disease, DKA, DI, severe dehydration, SAM, sickle cell crisis

Design outcomes

Primary

Measure	Time frame
PICU mortalityTimepoint: 28 days	—

Secondary

Measure	Time frame
PeLOD score Timepoint: 1-7;Cumulative fluid overloadTimepoint: Day 7;Ventilator free days (VFD)Timepoint: 28 days	—

Countries

India

Contacts

Public ContactDr Atul Jindal

All India Institute of Medical Sciences, Raipur

dratuljindal@gmail.com8224014667

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026