Health Condition 1: T300- Burn of unspecified body region, unspecified degree Health Condition 2: T200- Burn of unspecified degree of head, face, and neck Health Condition 3: T311- Burns involving 10-19% of body surface Health Condition 4: T312- Burns involving 20-29% of body surface Health Condition 5: T313- Burns involving 30-39% of body surface Health Condition 6: T314- Burns involving 40-49% of body surface Health Condition 7: T315- Burns involving 50-59% of body surface Health Condition 8:
Conditions
Interventions
Intervention1: vitamine C: Patient will receive injection Vit C 1.5 gm intravenous thrice daily for 5 days.
Intervention2: N-Acetyle Cysteine: Patient will receive N-Acetyl Cysteine 1gm intravenous t
Sponsors
All India Institute of Medical Sciences Bhubaneswar
Eligibility
Inclusion criteria
Inclusion criteria: Severe burn patients in ICU
Exclusion criteria
Exclusion criteria: pregnant and lactating mothers, patients with pre-existing hepatic, respiratory, cardiac, renal failure or coagulopathy, patients previously NAC, Vit C, and MT therapy and mortality within 5days of admission
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the change in Sequential Organ Failure Assessment (SOFA) Score for 14 days after antioxidant such as Vit C, NAC, and MT adjuvant therapy in severe burn patients.Timepoint: at baseline and everyday till 7 days followed by alternate day for next 7days after initiation of intervention | — |
Secondary
| Measure | Time frame |
|---|---|
| to determine Acute Physiology and Chronic Health Evaluation (APACHE) II, Simplified Acute Physiology Score (SAPS) II, Richmond Agitation Sedation Score (RASS), C-reactive protein (CRP) and the procalcitonin (PCT) levels, incidence of delirium, vasoactive infusion score (VIS), requirement of renal replacement therapy, days of ventilatory support, ICU stay, hospital length of stay and mortality.Timepoint: at baseline and everyday till 7 days followed by alternate day for next 7days after initiation of intervention | — |
Countries
India
Contacts
Public ContactDevishree Das
All India Institute of Medical Sciences
Outcome results
None listed