A randomized controlled trial to study the effect of nebulization with ketamine versus normal saline on postop sore throat in patient after intubation.

A randomized controlled trial to study the effect of preoperative nebulization with Ketamine versus normal saline on post-operative sore throat in patient after endotracheal intubation. - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/074593

Enrollment

100

Registered

2024-10-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Nebulization with Ketamine: 1 ml diluted with 4 ml distilled water for 2 minutes one year four month Control Intervention1: Nebulization with Normal Saline: 5 ml normal saline for 2 min

Eligibility

Inclusion criteria

Inclusion criteria: 1. Age 18–60 years of either sex. 2. American Society of Anesthesiologists (ASA) physical status class I and II. 3. Duration of surgery 2-3 hours.

Exclusion criteria

Exclusion criteria: 1. Patient refusal 2. History of preoperative sore throat 1 week prior to surgery 3. Oral / Head and neck surgeries 4. Asthma/ Chronic obstructive pulmonary disease 5. Morbid obesity 6. Difficult intubation (mallampati grade more than 2) 7. Patient requiring nasogastric tube 8. Allergies to study drug.

Design outcomes

Primary

Measure	Time frame
Incidence and severity of postoperative sore throat using POST score at 2hour,4hour,6hour and 12 hours after extubation in both the groups.Timepoint: Incidence and severity of postoperative sore throat using POST score at 2hour,4hour,6hour and 12 hours after extubation in both the groups.	—

Secondary

Measure	Time frame
Effect of preoperative nebulization with Ketamine and normal saline on hemodynamics (HR,BP)Timepoint: After 5 minutes of nebulization,vitals will be checked	—

Countries

India

Contacts

Public ContactDr Vibha Mehta

Maharaja Agrasen Medical College

drvibhamehta1@gmail.com9466088221

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026