A study to compare the effect of lignocaine and ketamine in reducing the analgesic requirement in the first 24 hours

Comparative study of the effect of lignocaine and ketamine as intra-operative and post-operative analgesics in elective surgeries under general anaestgesia- A randomized control trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/10/074581

Enrollment

150

Registered

2024-10-01

Start date

Unknown

Completion date

Unknown

Last updated

2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: 8- Other Procedures

Interventions

Intervention1: ketamine and lignocaine: Group A: 1.5 mg/kg IV bolus of lignocaine before induction, followed by a 3 hour continuous infusion of 1.5 mg/kg/hr Intervention2: ketamine and lignocaine: Gro

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged between 18 and 60 belonging to either sex undergoing elective surgery under General anaesthesia. 2. American Society of Anaesthesiologist 1 and 2

Exclusion criteria

Exclusion criteria: 1. Patients requiring postoperative mechanical ventilation 2. Pregnancy or Breastfeeding 3. Body mass index (=35 kg/m2) 4. Allergy to study drug 5. Contraindications to use of study medications such as cardiac, renal, hepatic disease, seizure or other neurological disorder, 6. Chronic substance abuse 7. History of chronic pain

Design outcomes

Primary

Measure	Time frame
To compare the effects of Ketamine and Lignocaine in reducing the analgesic requirements in peri-operatively for first 24 hours. Timepoint: 0,15mins,30mins,45mins,60mins,75mins,90mins,105mins,120mins.	—

Secondary

Measure	Time frame
1. VAS scores in post-operative patients. 2. Time of initial rescue analgesia. 3. Total number of analgesics used within the first 24 hours. 4. To observe nausea, vomiting, and shivering post-operatively. 5. To assess intraoperative and postoperative hemodynamic changes. Timepoint: 0,15mins,30mins,45mins,60mins,2hrs,4hrs,6hrs,8hrs,10hrs,12hrs,14hrs,16hrs,18hrs,20hrs,22hrs,24hrs.	—

Countries

India

Contacts

Public ContactBuvanesh

Sri Venkateshwaraa medical college Hospital and Research center

Dr.jayashridevi@gmail.com8754689690

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026