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Calcium gluconate in preventing post partum blood as loss as intervention in hypertensive women

Effect of prophylactic intravenous calcium gluconate compared to placebo on postpartum blood loss in women with hypertensive disorders of pregnancy at term gestation undergoing emergency caesarean delivery: A randomised, double-blinded, placebo-controlled. - nill

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2024/10/074578
Enrollment
140
Registered
2024-10-01
Start date
Unknown
Completion date
Unknown
Last updated
2024-10-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O169- Unspecified maternal hypertension,unspecified trimester

Interventions

Intervention1: Prophylactic intravenous calcium gluconate infusion: Women will receive 1g (10ml) of calcium gluconate in 90 ml of normal saline as infusion over 10mins. Control Intervention1: Placebo

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Women with hypertensive disorders of pregnancy aged 18 – 45 years at or beyond 37 weeks of gestation undergoing emergency cesarean delivery.

Exclusion criteria

Exclusion criteria: 1. Renal dysfunction with serum Creatinine > 1.0 mg/dl 2.Known history of maternal cardiac disease, including arrhythmia, ischemic, and congenital cardiac disease 3. Treatment with digoxin within the last 2 weeks 4. Pre-existing bleeding disorders/ established DIC 5. Patient with pulmonary edema 6. Patients with chronic hypertension and chronic hypertension with superimposed preeclampsia.

Design outcomes

Primary

MeasureTime frame
To study the efficacy of prophylactic intravenous calcium gluconate compared to placebo on postpartum blood loss in women with hypertensive disorders of pregnancy at term geastation undergoing emergency caesarean delivery. Timepoint: Intraoperative blood loss at the end of surgery and upto 2 hours post delivery—

Secondary

MeasureTime frame
1. To study the efficacy of prophylactic intravenous calcium gluconate compared to normal saline infusion on : 1.Incidence of PPH 2.Maternal hemodynamic status 3.Uterine tone 4.Need for additional uterotonic agents (methylergometrine/ prostaglandins F2alfa/E1) 5.Need for blood transfusions 6.Need for inotropic requirement 7.Need for other surgical interventions for management of PPH 2. To study the effect of prophylactic intravenous calcium gluconate infusions on maternal hemoglobin pre and post intervention. Timepoint: 2 HOURS POST PARTUM—

Countries

India

Contacts

Public ContactSupriya R

Jawaharlal Institute of Postgraduate Medical Education and Research

dr.niveditajha@gmail.com9487581663

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026