Comparison of Low-Dose Ketamine with Lignocaine vs. Dexmedetomidine for Safe and Comfortable Breathing Tube Placement in Patients with Difficult Airways

Comparison of effect of Subanesthetic dose of Intravenous Ketamine + Lignocaine versus Intravenous Dexmedetomidine on the intubating conditions and hemodynamic stability in awake fiberoptic intubation for anticipated difficult airway: a randomized clinical study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2024/09/074528

Enrollment

Registered

2024-09-30

Start date

Unknown

Completion date

Unknown

Last updated

2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical Health Condition 2: T888- Other specified complications of surgical and medical care, not elsewhere classified

Interventions

Intervention1: Ketamine, Lignocaine: Ketamine- 0.3 mg/kg bolus intravenous followed by 0.3 mg/kg/hr infusion intravenously until the procedure of fiberoptic intubation is completed Lignocaine- 1.5 mg

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients posted for elective surgeries 2.Patients with ASA status of 1 and 2 3.Patients with Anticipated Difficult Airway with Elâ??Ganzouri Score 4â??12

Exclusion criteria

Exclusion criteria: 1. Patients unwilling to give consent for the study 2. Patients with contraindications for awake fiberoptic intubation such as history of coagulopathies, base of skull fracture 3. Patients allergic to study medications 4. Patients with coexisting diseases like uncontrolled hypertension, asthma, history of MI,CAD, shock, heart blocks, heart failure 5. Pregnant women

Design outcomes

Primary

Measure	Time frame
Intubating conditions in terms of Modified Observer Assessment of Alertness/Sedation(OAA/S) score,Endoscopy time, Intubation time, Endoscopist satisfaction score,Patient Discomfort score, Patient Recall of procedureTimepoint: OAA/S score-Immediately before intubation Endoscopy time-from insertion of scope to carina visualization Intubation Time-from ET tube insertion to fiberscope is removed Endoscopist satisfaction-immediately after intubation Patient Discomfort score- During intubation Patient recall- 24 hours postoperatively	—

Measure

Time frame

Intubating conditions in terms of Modified Observer Assessment of Alertness/Sedation(OAA/S) score,Endoscopy time, Intubation time, Endoscopist satisfaction score,Patient Discomfort score, Patient Recall of procedureTimepoint: OAA/S score-Immediately before intubation Endoscopy time-from insertion of scope to carina visualization Intubation Time-from ET tube insertion to fiberscope is removed Endoscopist satisfaction-immediately after intubation Patient Discomfort score- During intubation Patient recall- 24 hours postoperatively

—

Secondary

Measure	Time frame
Hemodynamic Parameters(Heart rate, Mean Arterial Pressure, Oxygen Saturation)Timepoint: Baseline, after achieving desired sedation level, 1 minute intervals during the procedure, immediately after securing the endotracheal tube;Opioid requirement during procedureTimepoint: End of the procedure;Incidence of adverse eventsTimepoint: 24 hours postoperatively	—

Countries

India

Contacts

Public ContactDr.Jitendra Kalbande

All India Institute of Medical Sciences

drjitu222@gmail.com8368326094

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026